Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study

Arthritis Research & Therapy
Silje ReiseterAnna-Maria Hoffmann-Vold

Abstract

Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselected cohorts of SSc and MCTD. Sera of SSc patients (N = 298) and MCTD patients (N = 162) from two longitudinal Norwegian cohorts were included. Blood donors were included as controls (N = 100). Circulating VEGF and endostatin were analyzed by enzyme immunoassay. Mean endostatin levels were increased in SSc patients 93.7 (37) ng/ml (P < .001) and MCTD patients 83.2 (25) ng/ml (P < .001) compared to controls 65.1 (12) ng/ml. Median VEGF levels were elevated in SSc patients 209.0 (202) pg/ml compared to MCTD patients 181.3 (175) pg/ml (P = .017) and controls 150.0 (145) pg/ml (P < .001). Multivariable analysis of SSc subsets showed that pulmonary arterial hypertension (coefficient 15.7, 95 % CI: 2.2-29.2, P = .023) and scleroderma renal crisis (coefficient 77.6, 95 % CI: 59.3-100.0, P < .001) were associated with elevated endostatin levels. Multivariable analyses of MCTD subsets showed that digital ulcers were associated with elevat...Continue Reading

References

Aug 18, 2004·Lancet·Masataka KuwanaYasuo Ikeda
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Josephine Swanton, David Isenberg
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Thomas Grader-Beck, Fredrick M Wigley
Oct 6, 2005·The European Respiratory Journal·N MacintyreJ Wanger
Mar 3, 2007·Annals of the Rheumatic Diseases·Virginia D Steen, Thomas A Medsger
Jan 16, 2008·Radiology·David M HansellJacques Remy
Feb 21, 2009·The Journal of Rheumatology·Laura K HummersMichael Simons
Feb 10, 2010·Clinical Reviews in Allergy & Immunology·Eric Hachulla, David Launay
Nov 5, 2010·Seminars in Arthritis and Rheumatism·Soumya Chatterjee
Dec 18, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Lotta Seppinen, Taina Pihlajaniemi
Mar 15, 2011·Annals of the Rheumatic Diseases·Ragnar GunnarssonUNKNOWN PAHNOR1 Study Group
May 10, 2011·Autoimmunity Reviews·Vasiliki LiakouliRoberto Giacomelli
May 31, 2011·Annals of the Rheumatic Diseases·Jörg H W DistlerOliver Distler
Mar 10, 2012·Annals of the Rheumatic Diseases·Maria De SantisGianfranco Ferraccioli
Mar 20, 2012·Best Practice & Research. Clinical Rheumatology·Oscar-Danilo Ortega-Hernandez, Yehuda Shoenfeld
Apr 28, 2012·Rheumatology·Anna-Maria Hoffmann-VoldJan Tore Gran
Jul 7, 2012·Journal of Clinical Immunology·Wen-jia PengJing Wang
Aug 8, 2012·Trends in Cardiovascular Medicine·Mirko ManettiMarco Matucci-Cerinic
Sep 8, 2012·Current Opinion in Rheumatology·Lynne A MurrayErica L Herzog
Oct 16, 2012·Current Rheumatology Reports·Lesley Ann Saketkoo, Oliver Distler
Jan 8, 2013·Current Rheumatology Reports·Aaliya Yaqub, Lorinda Chung
May 3, 2013·The Journal of Rheumatology·Anna-Maria Hoffmann-VoldJan Tore Gran
May 3, 2013·The Journal of Rheumatology·Agota HajasEdit Bodolay
Aug 7, 2013·Indian Journal of Dermatology·Vishalakshi ViswanathVinay V Gopalani
Sep 3, 2013·International Journal of Rheumatic Diseases·Hanan Mohamed FaroukAl Hussein M El Dakrony
Sep 14, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Johan ÄrnlövLars Lind
May 17, 2014·The Journal of Rheumatology·Bahar Artim-EsenMurat Inanç
Sep 3, 2014·American Journal of Respiratory and Critical Care Medicine·Mike O BeckerGabriela Riemekasten
Jan 24, 2015·Seminars in Arthritis and Rheumatism·Nilanjana BoseSoumya Chatterjee

❮ Previous
Next ❯

Citations

Mar 15, 2016·Current Rheumatology Reports·Colin Ligon, Laura K Hummers
Jun 23, 2016·Metabolomics : Official Journal of the Metabolomic Society·Polona ŽigonSnezna Sodin-Semrl
Apr 25, 2018·Arthritis & Rheumatology·Anna-Maria Hoffmann-VoldØyvind Molberg
Jul 12, 2019·Pulmonary Circulation·Douglas BushFrancis Hickey
Oct 13, 2017·International Journal of Rheumatic Diseases·Andrea Delle SedieIlaria Puxeddu
Mar 30, 2019·Orphanet Journal of Rare Diseases·Anthony M LamattinaSouheil El-Chemaly
Nov 25, 2016·Experimental and Therapeutic Medicine·Simon Siao-PinSimona Rednic
May 10, 2018·Frontiers in Medicine·Javier Rodríguez-CarrioAna Suárez
Oct 16, 2020·Arthritis Research & Therapy·Michal A RahatDevy Zisman

❮ Previous
Next ❯

Software Mentioned

NOSVAR
STATA
SPSS

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.