Associations between circulating sex steroid hormones and leukocyte telomere length in men in the National Health and Nutrition Examination Survey

Andrology
S B CoburnM B Cook

Abstract

Preliminary evidence suggests that sex steroid hormones, such as danazol (a synthetic sex steroid hormone), may be involved in enhancing telomerase activity. Elucidating underlying mechanisms of telomerase activity may further therapeutic options for individuals with telomeropathies and potentially avert certain age-related conditions. Therefore, we conducted a cross-sectional study to investigate the relationship between circulating sex steroid hormones and SHBG with leukocyte telomere length among 499 males in NHANES (1999-2002 surveys). Sample-weighted linear regression analyses were conducted to assess age-adjusted and multivariable-adjusted estimates of associations. Estimates were rescaled to represent telomere length change in base pairs per half the value of the interquartile range of the independent variable. Estradiol and free estradiol were significantly inversely associated with leukocyte telomere length (βcontinuous per §IQR  = -61, p = 0.04; free estradiol βcontinuous per §IQR  = -67, p = 0.03). Testosterone, free testosterone, androstanediol glucuronide, and SHBG were not associated with leukocyte telomere length. The inverse association seen in this study indicates that a danazol-induced hypoestrogenic state cou...Continue Reading

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Citations

May 15, 2020·International Journal of Cancer. Journal International Du Cancer·Yingyu FengEmmanuel Stamatakis
Oct 31, 2020·Frontiers in Physiology·Jossimara Polettini, Marcia Guimarães da Silva
Aug 28, 2021·Journal of Neurovirology·Jacqueline Samantha WomersleySian Megan Joanna Hemmings
Oct 11, 2021·Translational Psychiatry·Yen-Feng LinMing-Chyi Huang

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