Associations between clinically diagnosed testicular hypofunction and systemic lupus erythematosus: a record linkage study

Clinical Rheumatology
Julia PakpoorM J Goldacre

Abstract

Systemic lupus erythematosus (SLE) has a high female predominance with a 9:1 female-to-male sex ratio, but males have poorer clinical outcomes than females. Gonadal hormones may mediate gender differences in SLE, but their role in SLE remains largely uncharacterised. We aimed to investigate a potential association between testicular hypofunction (TH), as a proxy for low testosterone levels, and SLE in males. A retrospective cohort study was conducted by analysing linked English national Hospital Episode Statistics (HES) and mortality data from 1999 to 2011. We calculated rates for SLE following TH, and TH following SLE, stratified and standardised by age, calendar year of first recorded admission, region of residence, and quintile of patients' Index of Deprivation score. The adjusted rate ratio (RR) of SLE following TH was 7.7 (95% confidence interval (95% CI) 2.5-18.1, p < 0.0001). The adjusted RR for TH following SLE was 6.5 (95% CI 2.1-15.1, p < 0.0001). The positive association between TH and SLE supports a hypothesis that low testosterone levels may influence the development of male SLE. Of clinical importance, it suggests that males with SLE are at increased risk of co-morbid TH (regardless of which precedes which) and th...Continue Reading

References

Jun 1, 1977·The Journal of Clinical Investigation·J R RoubinianN Talal
Apr 1, 1982·Arthritis and Rheumatism·P JungersJ F Bach
Aug 1, 1993·Journal of Epidemiology and Community Health·L GillM Griffith
Jan 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·V TomassiniC Pozzilli
Feb 1, 2007·Arthritis and Rheumatism·Rosa M AndradeUNKNOWN LUMINA Study Group
Sep 4, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·Alessandro F FoisMichael J Goldacre
Apr 13, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sara K TedeschiKaren H Costenbader
Apr 9, 2014·Multiple Sclerosis : Clinical and Laboratory Research·R BoveT Chitnis
Aug 6, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Julian GoldMichael Goldacre
Aug 19, 2014·Annals of Neurology·Julia PakpoorMichael J Goldacre

❮ Previous
Next ❯

Citations

Jan 29, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Marco Marcelli, Sanjay Navin Mediwala
Oct 20, 2018·Frontiers in Immunology·Vaishali R Moulton
Dec 19, 2018·Journal of Clinical Medicine·Abdulmaged TraishAbraham Morgentaler
Nov 7, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·William GrobeGerhard Haidl
Sep 26, 2020·Frontiers in Endocrinology·Eleni Magdalini Kyritsi, Christina Kanaka-Gantenbein
Oct 4, 2020·Nature Reviews. Rheumatology·Maurizio Cutolo, Rainer H Straub

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.