Associations between cognitive function, blood lead concentration, and nutrition among children in the central Philippines

The Journal of Pediatrics
Orville SolonJohn W Peabody

Abstract

Because little is known about its effects on cognitive function among children in less-developed countries, we determined the impact of lead exposure from other nutritional determinants of cognitive ability. Data were from a cross-sectional population-based stratified random sample of 877 children (age 6 months-5 years) participating in the Quality Improvement Demonstration Study we are conducting in the Philippines. With data from validated psychometric instruments, venous blood samples, and comprehensive survey instruments, we developed multi-stage models to account for endogenous determinants of blood lead levels (BLLs) and exogenous confounders of the association between BLLs and cognitive function. A 1 microg/dL increase in BLL was associated with a 3.32 point decline in cognitive functioning in children aged 6 months to 3 years and a 2.47 point decline in children aged 3 to 5 years olds. BLL was inversely associated with hemoglobin and folate levels. Higher folate levels mitigated the negative association between BLL and cognitive function. These population-based data suggest greater lead toxicity on cognitive function than previously reported. Our findings also suggest that folate and iron deficient children are more sus...Continue Reading

References

Dec 1, 1976·Archives of Disease in Childhood·R W SmithellsC J Schorah
Jun 1, 1992·Journal of Developmental and Behavioral Pediatrics : JDBP·G P Aylward
Mar 1, 1989·International Journal of Epidemiology·D BellingerC Waternaux
Feb 1, 1980·British Journal of Industrial Medicine·C N Ong, W R Lee
Aug 1, 1994·Journal of Developmental and Behavioral Pediatrics : JDBP·A W WolfB Lozoff
Nov 1, 1994·Pediatric Annals·D Bellinger, K N Dietrich
Nov 14, 1997·Journal of Developmental and Behavioral Pediatrics : JDBP·G P Aylward
Dec 31, 1997·Environmental Health Perspectives·G A WassermanJ H Graziano
Dec 16, 1998·JAMA : the Journal of the American Medical Association·S TongA J McMichael
Apr 4, 2000·British Medical Bulletin·S M Grantham-McGregor, C C Ani
May 29, 2000·The Proceedings of the Nutrition Society·S M Grantham-McGregorS Chang
Feb 13, 2001·Environmental Research·J CalderónF Díaz-Barriga
Mar 22, 2001·International Journal of Environmental Health Research·M LacasañaM Hernandez-Avila
Jun 11, 2002·Environmental Health Perspectives·Scott D GrosseRichard J Jackson
Sep 7, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Maureen Durkin
Jan 18, 2003·Annals of Tropical Paediatrics·Abdur RahmanHina S Zuberi
Apr 18, 2003·The New England Journal of Medicine·Richard L CanfieldBruce P Lanphear
Jun 17, 2004·Environmental Health Perspectives·Karin KollerLen Levy
Jan 27, 2005·Journal of the American College of Nutrition·Mi-Gyung LeeWon O Song
Jul 9, 2005·Environmental Health Perspectives·Bruce P LanphearRussell Roberts
Mar 2, 2006·Environmental Health Perspectives·Nitin B Jain, Howard Hu
Jun 15, 2006·Nutrition Reviews·Betsy LozoffTimothy Schallert
Nov 21, 2007·Bulletin of the World Health Organization·Travis J RiddellJohn W Peabody

❮ Previous
Next ❯

Citations

Jun 12, 2012·Biological Trace Element Research·Fengwei TianWei Chen
Feb 26, 2010·Developmental Neuropsychology·Melanie McDiarmid Nelson, Kimberly Andrews Espy
May 4, 2010·Annual Review of Nutrition·Katarzyna Kordas
Feb 23, 2010·Environmental Health : a Global Access Science Source·Massimo PizzolMikael Skou Andersen
May 15, 2009·International Journal of Environmental Research and Public Health·Amal K MitraS A M K Bashar
Aug 17, 2011·International Journal of Environmental Research and Public Health·David C Bellinger
May 28, 2010·The American Journal of Clinical Nutrition·J Richard PilsnerMauricio Hernández-Avila
Jul 27, 2011·Environmental Toxicology and Pharmacology·Yaping JinJun Yang
May 15, 2010·Toxicology Letters·Jitbanjong Tangpong, Soisungwan Satarug
Apr 22, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Soo-Churl ChoHyo-Won Kim
Mar 26, 2013·International Journal of Occupational Medicine and Environmental Health·Kinga PolańskaWojciech Hanke
Sep 25, 2012·Environmental Research·Jack CaravanosRichard Fuller
Jan 22, 2008·The Journal of Pediatrics·Robert O Wright
Oct 31, 2009·The Journal of Pediatrics·Teresa S Bowers
Jul 31, 2008·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Miroslav HabanPeter Massanyi
Feb 10, 2016·Environmental Health Perspectives·Shanshan ZhouRobert R H Anholt
Feb 5, 2019·Environmental Monitoring and Assessment·Mahmoud MohammadyanSomayeh Rahimi Moghadam
Feb 27, 2009·Journal of Environmental Monitoring : JEM·Ali BazziAaron M Linder
Aug 7, 2017·Environmental Science and Pollution Research International·Jianjun HeRuixue Huang
Jun 13, 2018·International Journal of Environmental Research and Public Health·Min-Jing LeeLiang-Jen Wang
Jan 22, 2010·Maternal and Child Health Journal·Jack K Leiss, Jonathan B Kotch
Jul 22, 2019·Environmental Health : a Global Access Science Source·Roberto G LucchiniAlessandro Alimonti
Aug 6, 2020·International Journal of Environmental Research and Public Health·Frances M NilsenNicolle S Tulve
Dec 17, 2014·Environmental Science and Pollution Research International·Enrique M OstreaJames Janisse
Jul 3, 2013·International Journal of Psychology : Journal International De Psychologie·Kim T FergusonGary W Evans
Feb 11, 2021·Risk Analysis : an Official Publication of the Society for Risk Analysis·Pamela R D WilliamsErnesto Sanchez-Triana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.