Abstract
This meta-analysis was conducted to estimate associations between CDKN2B antisense (CDKN2B-AS) polymorphisms and susceptibility to atherosclerotic cardio-cerebral vascular diseases (ASCVD). A systematic literature research of PubMed, Medline, Web of Science, Embase, and CNKI was performed to identify eligible studies. Overall, 34 studies were included for meta-analyses. Pooled overall analyses showed that rs1333040, rs1333049, rs2383206, and rs2383207 polymorphisms were associated with susceptibility to ASCVD in the whole population. Further analyses by ethnicity revealed that all investigated polymorphisms were associated with susceptibility to ASCVD in East Asians. Moreover, rs2383206, rs2383207, rs10757274, and rs10757278 polymorphisms were associated with susceptibility to ASCVD in West Asians, while rs2383206, rs10757274, and rs10757278 were associated with susceptibility to ASCVD in Caucasians. When we stratified eligible studies by type of disease, positive results were found for all investigated polymorphisms in patients with coronary artery disease (CAD) or myocardial infarction, whereas positive results were only detected for rs2383206 and rs10757274 polymorphisms in patients with ischemic stroke (IS). Our findings su...Continue Reading
References
May 13, 2004·JAMA : the Journal of the American Medical Association·Donald M Lloyd-JonesChristopher J O'Donnell
Sep 29, 2004·Circulation·Aldons J LusisGregg C Fonarow
Oct 6, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Björn MayerHeribert Schunkert
Apr 20, 2007·American Journal of Epidemiology·Alanna C MorrisonEric Boerwinkle
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Jul 24, 2010·European Journal of Epidemiology·Andreas Stang
Apr 14, 2011·Current Atherosclerosis Reports·Michael S Cunnington, Bernard Keavney
May 20, 2011·Nature·Peter LibbyGöran K Hansson
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Dec 20, 2011·Atherosclerosis·Ada CongrainsHiromi Rakugi
Jan 12, 2012·Circulation. Cardiovascular Genetics·George ThanassoulisChristopher J O'Donnell
Dec 26, 2012·Gene·Waqas AhmedRaheel Qamar
Apr 18, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Veronica J Peschansky, Claes Wahlestedt
Dec 21, 2014·The Annals of Pharmacotherapy·Lydia C Newsom
Dec 30, 2014·Cardiovascular & Hematological Agents in Medicinal Chemistry·Andrea RognoniAngelo S Bongo
Feb 4, 2016·World Journal of Cardiology·Xuming DaiMarschall S Runge
Apr 22, 2016·The Journal of Obstetrics and Gynaecology Research·Xiaohan ShiShangwei Li
May 18, 2016·EMBO Molecular Medicine·Thorsten KesslerHeribert Schunkert
Mar 14, 2017·Clinical and Experimental Hypertension : CHE·Xiaochuan XieLi Rao
May 6, 2017·Scandinavian Journal of Immunology·X XieM Liu
Aug 20, 2018·Gene·Yubing ZhuZhongwen Hu
Sep 4, 2018·Experimental and Molecular Pathology·Hao SunHongmei Qiao