Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears.

Environmental Research
Thea BechshøftGro D Villanger

Abstract

The multivariate relationship between hair cortisol, whole blood thyroid hormones, and the complex mixtures of organohalogen contaminant (OHC) levels measured in subcutaneous adipose of 23 East Greenland polar bears (eight males and 15 females, all sampled between the years 1999 and 2001) was analyzed using projection to latent structure (PLS) regression modeling. In the resulting PLS model, most important variables with a negative influence on cortisol levels were particularly BDE-99, but also CB-180, -201, BDE-153, and CB-170/190. The most important variables with a positive influence on cortisol were CB-66/95, α-HCH, TT3, as well as heptachlor epoxide, dieldrin, BDE-47, p,p'-DDD. Although statistical modeling does not necessarily fully explain biological cause-effect relationships, relationships indicate that (1) the hypothalamic-pituitary-adrenal (HPA) axis in East Greenland polar bears is likely to be affected by OHC-contaminants and (2) the association between OHCs and cortisol may be linked with the hypothalamus-pituitary-thyroid (HPT) axis.

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Citations

May 8, 2013·Chemosphere·Simon E ErdmannEva C Bonefeld-Jørgensen
Mar 3, 2015·Environmental Toxicology and Chemistry·Sandra HuberLinda Hanssen
Jun 6, 2015·Ecotoxicology·T BechshoftV L St Louis
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Apr 29, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Shannon AtkinsonKendall Mashburn
Sep 23, 2016·Conservation Physiology·Josué H RakotoniainaCornelia Kraus
Jan 6, 2017·Environmental Toxicology and Chemistry·Sara VillaMarco Vighi
Sep 8, 2018·Endocrine·Darya Saeed Abdulateef, Taha Othman Mahwi
Aug 16, 2019·The Science of the Total Environment·Thea BechshoftVincent St Louis
Feb 5, 2014·Environmental Science & Technology·Marie NoëlPeter S Ross

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