Associations between cruciferous vegetable intake and selected biomarkers among women scheduled for breast biopsies.

Public Health Nutrition
Zhenzhen ZhangJackilen Shannon

Abstract

To examine the relationship between dietary cruciferous vegetable intake and selected tumour biomarkers for histone acetylation (H3K9ac, H3K18ac, HDAC3 and HDAC6), proliferation (Ki-67) and cell-cycle regulation (p21) from breast tissue. The study used baseline data of women recruited to participate in a clinical trial of sulforaphane supplement. Dietary cruciferous vegetable intake was collected through a validated Arizona Cruciferous Vegetable Intake Questionnaire. Breast tissue was obtained from biopsy samples. Spearman correlations were calculated between intake of specific cruciferous vegetables and biomarkers. Tissue biomarkers were log2-transformed to obtain approximate normality. Linear regression analyses were conducted to examine associations between cruciferous vegetable intake and biomarkers adjusting for age and use of non-steroidal anti-inflammatory drugs. False discovery rate (FDR) was used to account for multiple comparisons. Clinical trial baseline. Fifty-four women who had abnormal mammogram findings and were scheduled for breast biopsy. Mean intake of total cruciferous vegetables from all food sources was 81·7 (sd 57·3) g/d. Mean urinary total sulforaphane metabolites was 0·08 (sd 0·07) µm/mm creatinine. Tota...Continue Reading

Associated Clinical Trials

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangG H Posner
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J W FaheyP Talalay
Feb 15, 2001·JAMA : the Journal of the American Medical Association·S A Smith-WarnerD J Hunter
Feb 22, 2002·Gynecologic Oncology·Elizabeth M SwisherDavid G Mutch
Jan 28, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gabrielle RouzaudAlan J Duncan
Mar 7, 2007·Molecular Cancer Therapeutics·Allison Pledgie-TracyNancy E Davidson
Mar 27, 2007·Journal of the American Dietetic Association·Cynthia A ThomsonIman A Hakim
Feb 24, 2011·The British Journal of Nutrition·Fei LiJohanna W Lampe
May 20, 2011·The American Journal of Clinical Nutrition·Xianglan ZhangWei Zheng
Aug 6, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·John D ClarkeEmily Ho
Mar 6, 2012·Journal of Food Composition and Analysis : an Official Publication of the United Nations University, International Network of Food Data Systems·Bethany L SixCarol J Boushey
Aug 11, 2012·The Breast : Official Journal of the European Society of Mastology·Xiaojiao Liu, Kezhen Lv
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Ahmad Faizal Abdull Razis, Noramaliza Mohd Noor
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Xue-Ou LiuKe-Xin Chen
Mar 19, 2014·Journal of the Academy of Nutrition and Dietetics·Yu JiangGong Yang
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Feb 23, 2018·Molecular Nutrition & Food Research·Dushani L PalliyaguruJed W Fahey
Sep 3, 2017·European Journal of Nutrition·Paola ArcidiaconoRoberta Spaccapelo
May 18, 2019·Advances in Nutrition·McKale Montgomery, Aishwarya Srinivasan
Aug 6, 2020·Nutrients·Dushani L PalliyaguruThomas W Kensler
Jul 25, 2017·Journal of Cell Communication and Signaling·Reza Bayat MokhtariHerman Yeger
Oct 11, 2019·Cells·Mohammad Mijanur RahmanTrygve O Tollefsbol
Nov 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Parham Jabbarzadeh KaboliZhangang Xiao
Mar 13, 2021·Free Radical Biology & Medicine·Qi Wang, Yongping Bao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

The Breast : Official Journal of the European Society of Mastology
Xiaojiao Liu, Kezhen Lv
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
A HoqueS M Lippman
Nederlands tijdschrift voor geneeskunde
A C Voogd, M F Ernst
© 2021 Meta ULC. All rights reserved