Associations between Depressive Disorders and Inflammatory Rheumatic Diseases

Current Topics in Medicinal Chemistry
Özkan VaranBerna Göker

Abstract

Depressive disorders, are not only common but also among the leading causes of disability worldwide. They are associated with increased incidences of various other diseases. It has been shown that in patients with autoimmune diseases, when depression coexists, the quality of life is worse and medical treatment and management is compromised. Depression-like symptoms, such as fatigue and disinterest are also common in inflammatory rheumatic diseases and often associated with poor quality of life. Medical therapy targeting inflammation results in alleviation of these symptoms in many patients. Interestingly, there is cumulating evidence suggesting potential roles of inflammatory cytokines in the pathogenesis of major depression. Effects of some of the biological agents used in rheumatic diseases have been studied on depressive disorders. Results have been controversial and further studies are needed in this area. These findings suggest associations between depression and inflammatory rheumatic diseases and raise the possibility that treatment of one of them might influence the outcome of the other. We have reviewed the current literature on associations between depression and inflammatory rheumatologic diseases, such as rheumatoid...Continue Reading

Citations

Nov 5, 2019·Rheumatology·S Mechiel Korte, Rainer H Straub
Jul 3, 2020·Current Topics in Medicinal Chemistry·Hande Sipahi, Eva Reininghaus
Nov 30, 2018·Zeitschrift für Rheumatologie·C BaerwaldA Hueber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Baillière's Best Practice & Research. Clinical Rheumatology
C Ramos-RemusF Galvan-Villegas
Journal of the American Pharmaceutical Association : APhA
Arthur A Schuna
The Tohoku Journal of Experimental Medicine
M FunauchiA Horiuchi
Scandinavian Journal of Rheumatology
M J Leandro, D A Isenberg
© 2022 Meta ULC. All rights reserved