Associations between Dietary Inflammatory Index Scores and Inflammatory Biomarkers among Older Adults in the Lothian Birth Cohort 1936 Study

The Journal of Nutrition, Health & Aging
Janie CorleyIan J Deary

Abstract

Chronic low-grade inflammation is a key underlying mechanism in several age-related chronic conditions and previous studies have shown that diet can modulate the inflammatory process. We investigated the ability of the Dietary Inflammatory Index (DII®), a summary measure of dietary inflammatory potential, to predict concentrations of plasma inflammatory markers in a sample of older people. Cross-sectional and 3-year follow-up analysis of Lothian Birth Cohort 1936 (LBC1936) study data. Baseline data collection occurred between 2004 and 2007 in Edinburgh, Scotland. Men and women (n 928, age ~70 at baseline) living in Edinburgh and surrounding regions who are surviving participants of the Scottish Mental Survey of 1947. Energy-adjusted DII (E-DII) scores at age 70 (derived from a food-frequency questionnaire), plasma concentrations of inflammatory biomarkers at age 70 (C-reactive protein (CRP), fibrinogen) and age 73 (CRP, fibrinogen, hs-CRP, Interleukin-6 (IL-6)). Analyses were performed using multivariable logistic regression adjusting for age, sex, smoking, body mass index, physical activity, and hypercholesterolaemia. Higher E-DII scores (pro-inflammatory diet) were associated with increased odds of elevated CRP (>3mg/L) at ag...Continue Reading

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Citations

Jan 25, 2020·Nutrients·Lucas Jurado-FasoliFrancisco J Amaro-Gahete
Nov 6, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Mahdi VajdiMahsa Mahmoudi-Nezhad
Nov 14, 2020·International Journal of Environmental Research and Public Health·Fatima NariSung-In Jang
Jan 25, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Prem Raj ShakyaTiffany K Gill
Apr 27, 2021·Journal of Clinical Periodontology·An LiGeerten-Has E Tjakkes
Sep 25, 2021·The American Journal of Clinical Nutrition·Courtney L MillarShivani Sahni

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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