Associations between different bilirubin subtypes and diabetic microvascular complications in middle-aged and elderly individuals

Therapeutic Advances in Endocrinology and Metabolism
Heng WanYingli Lu

Abstract

Some studies have reported associations between bilirubin and diabetic microvascular complications. However, these studies focused only on total bilirubin (TBIL) without distinguishing different bilirubin subtypes. In this study, we aimed to investigate the associations of TBIL, direct bilirubin (DBIL) and indirect bilirubin (IBIL) levels with albuminuria/creatinine ratio (ACR) and the prevalence of diabetic retinopathy (DR) among diabetic adults. We analyzed 4368 individuals out of 4813 diabetic participants enrolled from seven communities in 2018 in a cross-sectional study. Participants underwent several checkups, including the measurement of anthropometric parameters, blood pressure, glucose, lipid profile, TBIL, DBIL, IBIL and ACR. DR was detected by high-quality fundus photographs and was remotely read by ophthalmologists. Compared with the first quartile of DBIL, participants in the fourth quartile had a lower prevalence of high ACR (odds ratio (OR) 0.76; 95% confidence interval (CI) 0.59, 0.99) (p for trend < 0.05). Neither TBIL nor IBIL was associated with the prevalence of high ACR. In DR, higher DBIL and TBIL by one standard deviation was associated with a 19% (OR 0.81; 95% CI 0.69, 0.94) and a 12% (OR 0.88; 95% CI 0....Continue Reading

References

Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R Stocker, B N Ames
Jan 28, 2003·Journal of Neuroscience Research·Yoshihisa KitamuraShun Shimohama
Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
Dec 14, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Erh-Jung HuangShin-Da Lee
Apr 26, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sandra PinedaBruce Ovbiagele
May 25, 2010·The Tohoku Journal of Experimental Medicine·Seung Seok HanHo Jun Chin
Jun 15, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hee-Jin Hwang, Sang-Hwan Kim
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Yu XuUNKNOWN 2010 China Noncommunicable Disease Surveillance Group
Sep 17, 2013·Journal of Diabetes·Syeda Sadia NajamGuang Ning
Sep 26, 2013·The American Journal of Cardiology·Ki-Chul SungChristopher D Byrne
Apr 25, 2015·Diabetes·William Durante
Dec 10, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ningjian WangYingli Lu
Aug 16, 2016·Trends in Molecular Medicine·Silvia GazzinClaudio Tiribelli
Jan 18, 2017·BMJ : British Medical Journal·Willy Marcos Valencia, Hermes Florez
Jul 21, 2017·Diabetologia·Josephine M Forbes, Amelia K Fotheringham
Oct 24, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ryoichi FujiwaraMatthias Schwab
Mar 3, 2018·Diabetes Research and Clinical Practice·N H ChoB Malanda
Jul 10, 2018·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Y-J KwonJ-W Lee
Oct 26, 2018·Hypertension·Terry D Hinds, David E Stec
Apr 24, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Heng WanYingli Lu
Jan 9, 2020·Diabetes Research and Clinical Practice·Heng WanYingli Lu

❮ Previous
Next ❯

Software Mentioned

SPSS Statistics
Empower
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Hongchuang ZhangXiaomeng Song
© 2021 Meta ULC. All rights reserved