Associations between etiologic factors and mortality after endometrial cancer diagnosis: the NRG Oncology/Gynecologic Oncology Group 210 trial

Gynecologic Oncology
Ashley S FelixLouise A Brinton

Abstract

Few studies have analyzed relationships between risk factors for endometrial cancer, especially with regard to aggressive (non-endometrioid) histologic subtypes, and prognosis. We examined these relationships in the prospective NRG Oncology/Gynecologic Oncology Group 210 trial. Prior to surgery, participants completed a questionnaire assessing risk factors for gynecologic cancers. Pathology data were derived from clinical reports and central review. We used the Fine and Gray subdistribution hazards model to estimate subhazard ratios (HRs) and 95% confidence intervals (CIs) for associations between etiologic factors and cause-specific subhazards in the presence of competing risks. These models were stratified by tumor subtype and adjusted for stage and socioeconomic status indicators. Median follow-up was 60months after enrollment (range: 1day-118months). Among 4609 participants, a total of 854 deaths occurred, of which, 582 deaths were attributed to endometrial carcinoma. Among low-grade endometrioid cases, endometrial carcinoma-specific subhazards were significantly associated with age at diagnosis (HR=1.04, 95% CI=1.01-1.06 per year, P-trend) and BMI (class II obesity vs. normal BMI: HR=2.29, 95% CI=1.06-4.98, P-trend=0.01). ...Continue Reading

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Citations

Jun 2, 2016·Pharmaceutical Research·Aliyah AlmomenMargit M Janát-Amsbury
Sep 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhiguo LiDefeng Kuang
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Sep 4, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Renée L Kokts-PorietisChristine M Friedenreich

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