Associations between executive function impairment and biochemical abnormalities in bipolar disorder with suicidal ideation

Journal of Affective Disorders
Shuming ZhongYanbin Jia

Abstract

Executive dysfunction and biochemical abnormalities using proton magnetic resonance spectroscopy (1H-MRS) have been reported in bipolar disorder (BD). Much less is known about the information from BD with suicidal ideation (SI). This study aimed to assess alterations of execution function and biochemical metabolism in BD with SI, in BD without SI, and in healthy controls. The associations between execution function and biochemical metabolism in the two BD patient groups were also been studied. 92 patients with bipolar disorder during a depressive episode (50 with current SI, and 42 without SI), as well as, 43 healthy controls were recruited in our study. Executive function was assessed by Wisconsin Card Sorting Test (WCST). Bilateral metabolite levels of prefrontal cortex (PFC), anterior cingulated cortex (ACC), lenticular nucleus (LN) of basal ganglia and thalamus were obtained by 1H-MRS at 3.0 T, then determined the ratios of N-acetyl aspartate (NAA), choline-containing compounds (Cho), myo-inositol (mI) to creatine (Cr). Number of categories completed (CC) in BD with SI was significantly less than healthy controls. NAA/Cr ratios of left PFC in the two BD patient groups (with or without SI) were significantly lower than healt...Continue Reading

Citations

Feb 15, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Estêvão Scotti-MuzziMarcio Gerhardt Soeiro-de-Souza
Apr 22, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M G Soeiro-de-SouzaR Machado-Vieira

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