Associations between FCGR polymorphisms and immune thrombocytopenia: A meta-analysis

Scandinavian Journal of Immunology
Gang LiLing Mingzhi

Abstract

Several studies already explored associations between Fc gamma receptor (FCGR) polymorphisms and immune thrombocytopenia (ITP), but the results of these studies were not consistent. Consequently, we conducted a meta-analysis of relevant studies to better analyse the effects of FCGR polymorphisms on individual susceptibility to ITP. PubMed, Web of Science, Embase and CNKI were searched for eligible studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Totally 17 studies were eligible for analyses (1200 cases and 1723 controls). Significant associations with ITP were observed for FCGR3A F158V polymorphism in dominant (P < 0.0001, OR = 0.47, 95% CI 0.39-0.57), recessive (P < 0.0001, OR = 2.03, 95% CI 1.58-2.61), overdominant (P < 0.0001, OR = 1.42, 95% CI 1.19-1.69) and allele (P < 0.0001, OR = 0.58, 95% CI 0.51-0.65) models in overall analyses. But we did not observe any significant associations with ITP for FCGR2A H131R and FCGR2B I232T polymorphisms in overall analyses. Subgroup analyses by ethnicity yielded similar positive results for FCGR3A F158V polymorphism in both Asians and Caucasians. Furthermore, subgroup analyses by type of disease revealed that FCGR2A H131R polymorphism was significantly asso...Continue Reading

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Citations

Aug 17, 2019·Scandinavian Journal of Immunology·Morteza GholamiFarshad Sharifi
Sep 15, 2019·Scandinavian Journal of Immunology·Sora Yasri, Viroj Wiwanitkit
Nov 16, 2019·The Journal of Gene Medicine·Yingling Zhao, Juheng Li
Mar 23, 2020·Cellular Immunology·Milos KosticGoran Marjanović

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