Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk)

Free Radical Biology & Medicine
Anna VogiatzoglouGunter G C Kuhnle

Abstract

Dietary intervention studies suggest that flavan-3-ol intake can improve vascular function and reduce the risk of cardiovascular diseases (CVD). However, results from prospective studies failed to show a consistent beneficial effect. Associations between flavan-3-ol intake and CVD risk in the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) were investigated. Data were available from 24,885 (11,252 men; 13,633 women) participants, recruited between 1993 and 1997 into the EPIC-Norfolk study. Flavan-3-ol intake was assessed using 7-day food diaries and the FLAVIOLA Flavanol Food Composition database. Missing data for plasma cholesterol and vitamin C were imputed using multiple imputation. Associations between flavan-3-ol intake and blood pressure at baseline were determined using linear regression models. Associations with CVD risk were estimated using Cox regression analyses. Median intake of total flavan-3-ols was 1034mg/d (range: 0-8531mg/d) for men and 970mg/d (0-6695mg/d) for women, median intake of flavan-3-ol monomers was 233mg/d (0-3248mg/d) for men and 217 (0-2712mg/d) for women. There were no consistent associations between flavan-3-ol monomer intake and baseline systolic an...Continue Reading

References

Jan 1, 1997·Hypertension·N K HollenbergM Vicaria-Clement
Mar 27, 2002·International Journal of Epidemiology·Nicholas J WarehamNicholas E Day
Oct 4, 2005·Journal of the American College of Cardiology·Christian HeissMalte Kelm
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hagen SchroeterMalte Kelm
Nov 6, 2007·The British Journal of Nutrition·Xenofon TzounisJeremy P E Spencer
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Apr 17, 2008·Journal of Agricultural and Food Chemistry·C Andres-LacuevaR M Lamuela-Raventós
Nov 13, 2008·BMC Medical Research Methodology·Shubhada SinhaKay-Tee Khaw
Mar 27, 2010·The International Journal of Cardiovascular Imaging·Yoichi InabaSteven R Bergmann
Apr 30, 2010·Database : the Journal of Biological Databases and Curation·V NeveuA Scalbert
Sep 21, 2010·European Heart Journal·Christian HeissMalte Kelm
Sep 22, 2010·Molecular Aspects of Medicine·Hagen SchroeterHarold H Schmitz
Nov 26, 2010·The American Journal of Clinical Nutrition·Aedín CassidyEric B Rimm
Aug 2, 2011·Journal of the American Dietetic Association·Harm H H FeringaCraig I Coleman
Nov 15, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gary Nichols
Jan 6, 2012·The American Journal of Clinical Nutrition·Marjorie L McCulloughJohanna T Dwyer
Mar 1, 2012·Stroke; a Journal of Cerebral Circulation·Aedín CassidyKathryn M Rexrode
Mar 2, 2012·The American Journal of Clinical Nutrition·Javier I OttavianiHagen Schroeter
May 4, 2012·The American Journal of Clinical Nutrition·Sabine EllingerHans-Peter Helfrich
Feb 26, 2014·European Journal of Nutrition·Joanne R LuptonJohn Hathcock
Nov 21, 2014·The American Journal of Clinical Nutrition·Cécilia SamieriFrancine Grodstein

❮ Previous
Next ❯

Citations

May 27, 2015·PloS One·Anna VogiatzoglouGunter G C Kuhnle
Oct 23, 2016·Free Radical Biology & Medicine·Gina BorgesAlan Crozier
Sep 10, 2016·The Proceedings of the Nutrition Society·Kathrin PallaufGerald Rimbach
Jan 29, 2020·Antioxidants & Redox Signaling·Irundika H K DiasHelen R Griffiths
Jan 15, 2020·Plant Foods for Human Nutrition·Paloma K Barrera-ReyesM Elizabeth Tejero
Apr 30, 2020·Food & Function·Gema Pereira-CaroAlan Crozier
Jul 30, 2020·Food & Function·Benjamin H ParmenterNicola P Bondonno
Jun 28, 2018·European Journal of Nutrition·P K Barrera-ReyesM E Tejero
Aug 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan TauchenMichal Jurášek
Feb 10, 2021·Molecular Nutrition & Food Research·Agnieszka MicekGiuseppe Grosso
Sep 3, 2021·The British Journal of Nutrition·Ze-Kai FanDuo Li

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

STROBE
Explorer
Phenol
Stata
ENCORE
DINERMO
DINER

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.