Associations between G/A1229, A/G3944, T/C30875, C/T48200 and C/T65013 genotypes and haplotypes in the vitamin D receptor gene, ultraviolet radiation and susceptibility to prostate cancer

Annals of Human Genetics
Sam MoonRichard C Strange

Abstract

Ultraviolet radiation (UVR) may protect against prostate cancer via a mechanism involving vitamin D. Thus, the vitamin D receptor (VDR) gene is a susceptibility candidate, though published data are discrepant. We studied the association of prostate cancer risk with five VDR single nucleotide polymorphisms (SNPs): G/A(1229) (SNP 1), A/G(3944) (SNP 2), T/C(30875) (SNP 3), C/T(48200) (SNP 4) and C/T(65013) (SNP 5), in 430 cancer and 310 benign prostatic hypertrophy (BPH) patients. The SNP 2 GG genotype frequency was lower in cancer than BPH patients (odds ratio = 0.63, 95% CI = 0.41-0.98, p = 0.039). SNPs 1 and 2, and SNPs 4 and 5, were in linkage disequilibrium. Two copies of haplotypes comprising SNPs 1-2, G-G (odds ratio = 0.63, p = 0.039), SNPs 2-3 G-C (odds ratio = 0.45, p = 0.008) and SNPs 1-2-3 G-G-C (odds ratio = 0.44, p = 0.006), but not SNPs 1-3, G-C (odds ratio = 0.81, p = 0.34), were associated with reduced risk (reference, no copies of the haplotypes). These associations were observed after stratification of subjects by extent of UVR exposure. These data show that SNP 2 GG genotype mediates prostate cancer risk, complementing studies reporting this allele is protective in malignant melanoma pathogenesis. They further ...Continue Reading

References

Jul 1, 1993·Molecular and Cellular Biology·M Merika, S H Orkin
Jan 15, 1997·Journal of the National Cancer Institute·S A InglesG A Coetzee
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A CroftsJ A Eisman
Nov 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C GrossD Feldman
Jan 21, 2000·Molecular Carcinogenesis·D G BlazerJ A Taylor
Sep 15, 2000·Human Genetics·L Correa-CerroW Vogel
Nov 15, 2000·Cancer Causes & Control : CCC·M H AhonenP Tuohimaa
May 30, 2001·Molecular and Cellular Endocrinology·G K WhitfieldM R Haussler
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H AraiE Takeda
Aug 14, 2001·Journal of Cellular Biochemistry·D KrillR H Getzenberg
Mar 29, 2002·The Prostate·Andrea GsurMichael Micksche
Mar 3, 2004·Environmental and Molecular Mutagenesis·Dhaval BodiwalaRichard C Strange
Mar 18, 2004·Journal of the National Cancer Institute·Sholom WacholderNathaniel Rothman
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen

❮ Previous
Next ❯

Citations

Apr 30, 2009·Annual Review of Nutrition·Marjorie L McCulloughTinisha L Mayo
Sep 13, 2007·International Journal of Medical Sciences·Mariko NaitoTakeo Nakayama
Oct 13, 2011·Advances in Preventive Medicine·Krishna Vanaja Donkena, Charles Y F Young
Jul 21, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Juliette A Randerson-MoorJulia A Newton Bishop
Jan 6, 2010·International Journal of Endocrinology·S KaramiL E Moore
Apr 16, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ching-Yu YenHsueh-Wei Chang
Mar 5, 2011·Molecular Oncology·Sinead Field, Julia A Newton-Bishop
Apr 23, 2009·Multiple Sclerosis : Clinical and Laboratory Research·J L DickinsonT Dwyer
Dec 5, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Gary G Schwartz, Halcyon G Skinner
Oct 13, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Crystal N HolickUlrike Peters

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.