PMID: 26795201Jan 23, 2016Paper

Associations Between Genetic Variants in 19p13 and 19q13 Regions and Susceptibility to Alzheimer Disease: A Meta-Analysis

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Jie BaoZong-fu Mao

Abstract

Alzheimer disease (AD) has become an epidemic within the growing elderly population and effective therapies of AD have not been discovered. Genetic factors accounted for over 70% of the incidence of AD and the disease-related polymorphisms are located on chromosome 19, which is one of several prominent chromosomes related to the development of AD. Many inconsistent associations between polymorphisms in ABCA7, CD33, and TOMM40 genes and the susceptibility to AD have been suggested by several independent studies. A comprehensive literature search for studies involving the association between gene polymorphisms and AD was performed, and we finally selected 3 genes (4 polymorphisms) for the meta-analysis: ABCA7 (rs3764650), CD33 (rs3865444), and TOMM40 (rs157580, rs2075650). A total of 25 articles investigating 3 genes (4 polymorphisms) were included in the meta-analysis. The pooled results of 4 polymorphisms were all significantly associated with the susceptibility to AD. The pooled effect of ABCA7 rs3764605 allele G was significantly associated with an increased the risk of AD (OR=1.20, 95% CI: 1.14-1.26, P value <0.001). Similarly, our evidence suggested that allele A of TOMM40 rs2075650 polymorphism was a risk factor for AD (OR...Continue Reading

Citations

Feb 24, 2020·Journal of Molecular Neuroscience : MN·Vasileios SiokasEfthimios Dardiotis
May 31, 2020·Molecular Genetics & Genomic Medicine·Selma M SoyalSerge Weis
Aug 3, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Sarah Teuber-HanselmannKathy Keyvani
Nov 22, 2018·Aging Cell·Alexander M KulminskiUNKNOWN Long Life Family Study Research Group
Aug 7, 2017·Biomedical Reports·Mohan GiriJayanti Chamling Rai
Mar 6, 2018·Journal of Molecular Neuroscience : MN·Jucimara Ferreira Figueiredo AlmeidaFlavia de Paula
May 22, 2018·Journal of Alzheimer's Disease : JAD·Fang-Chen MaJin-Tai Yu
Mar 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Stevan A SpringerPascal Gagneux
May 10, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chun-Han Liu, Lian Liu
Dec 21, 2020·Neuropathology and Applied Neurobiology·Arne HerringKathy Keyvani

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