Associations between glycaemic deterioration and aortic stiffness and central blood pressure: the ADDITION-PRO Study

Journal of Hypertension
Nanna B JohansenDaniel R Witte

Abstract

In the context of screening for diabetes, we examined levels of central haemodynamics among individuals with different levels of diabetes risk and analysed the impact of glycated haemoglobin A (HbA1c) and HbA1c changes on central haemodynamics. A Danish population-based stepwise screening programme for diabetes including a diabetes risk score (DRS) questionnaire and glucose measurements identified seven groups of individuals at increasing levels of diabetes risk. After 7.8 years of follow-up, 2048 individuals underwent aortic stiffness assessment by carotid-femoral pulse wave velocity (aPWV) and assessment of central blood pressure (BP). We compared differences in central haemodynamics at follow-up between the diabetes risk groups and analysed the impact of HbA1c at screening and HbA1c change on central haemodynamics at follow-up adjusting for relevant confounders. At screening, median age was 59.0 years, and median HbA1c was 5.7%. At follow-up, median aPWV was 8.0 m/s, and median central SBP was 123.5 mmHg. Among individuals with high DRS, aPWV, central SBP and DBP, and pulse pressure were higher in individuals with impaired glucose tolerance than normal glucose tolerance. Per 1%-point higher HbA1c at screening, aPWV was 0.23 ...Continue Reading

References

Nov 4, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T LauritzenUNKNOWN Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care
Feb 28, 2004·Diabetes Care·Charlotte GlümerUNKNOWN inter99 study
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Apr 11, 2008·The Journal of Clinical Hypertension·Wilmer W NicholsMichael F O'Rourke
Mar 4, 2010·European Heart Journal·Charalambos VlachopoulosChristodoulos Stefanadis
Mar 5, 2010·The New England Journal of Medicine·Elizabeth SelvinFrederick L Brancati
Mar 27, 2010·Journal of the American College of Cardiology·Charalambos VlachopoulosChristodoulos Stefanadis
May 18, 2010·European Heart Journal·Bryan Williams, Peter S Lacy
Sep 10, 2011·Drugs·Pierre BoutouyrieAzra Mahmud
Dec 14, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Solveig K MatthesenErling B Pedersen
Jan 4, 2012·Diabetes Care·UNKNOWN American Diabetes Association
Jan 10, 2012·Gerontology·David R Sell, Vincent M Monnier
Jan 27, 2012·Journal of Hypertension·Luc M Van BortelUNKNOWN European Network for Noninvasive Investigation of Large Arteries
May 26, 2012·PloS One·Nanna B JohansenDaniel R Witte
Aug 13, 2014·European Heart Journal·Annie HerbertUNKNOWN Reference Values for Arterial Measurements Collaboration

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Citations

Dec 16, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Alexandre ValléeJacques Blacher

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