Associations between GSTM1 and OGG1 Ser326Cys polymorphisms and smoking on chromosomal damage and birth growth in mothers.

Molecular Biology Reports
Bensu KarahalilElif Akkaş

Abstract

The presenting study was investigated the associations between individual susceptibility and cigarette smoke on maternal chromosomal damage and neonatal birth growth in smoking mothers since little known about genetic susceptibility to cigarette smoke in relation to adverse pregnancy outcome such as birth growth. Sixty-one pregnant women who completed a questionnaire at Ankara Education and Research Hospital, Department of Obstetrics and Gynecology have enrolled in this study. GSTM1 and OGG1 ser326Cys gene polymorphisms were analysed by RFLP-PCR (Restriction Fragment Length Polymorphism-Polymerase Chain Reaction) as possible genetic factors affecting susceptibility to such health effects of smoking and chromosomal damage was performed by chromosomal aberration assay (CAA) in maternal blood lymphocytes. Maternal self-reported history of pregnancy smoking was informed by questionnaire declaration. Our results showed that maternal smoking had significant effect on chromosomal damage, birth weight, and length. The frequencies of CA in smokers was significantly higher than that of the nonsmokers (3.46 ± 2.06 and 2.00 ± 1.3, P = 0.001). Birth weight and length in smokers were significantly higher that of nonsmokers (3,355 g and 49.57...Continue Reading

References

Nov 14, 1998·Archives of Environmental Health·S TabacovaL Balabaeva
Dec 22, 1999·International Journal of Epidemiology·I StückerD Hémon
Feb 24, 2001·Molecular and Cellular Biochemistry·S Qanungo, M Mukherjea
Jan 12, 2002·JAMA : the Journal of the American Medical Association·Xiaobin WangXiping Xu
May 2, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiroki OhmiYoshikatsu Mochizuki
May 29, 2002·Free Radical Biology & Medicine·Miral DizdarogluHenry Rodriguez
Jun 18, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Serena MasettiMaria Grazia Andreassi
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J A StuartV A Bohr
Jul 9, 2004·Environmental Health Perspectives·Frederica P PereraRobin M Whyatt
Dec 2, 2004·Mutation Research·David M DeMarini
Feb 23, 2005·Cancer Letters·Zsolt RadakIldiko Horvath
Feb 23, 2007·Birth Defects Research. Part C, Embryo Today : Reviews·Joanne Wan, Louise M Winn
Oct 14, 2008·American Journal of Perinatology·Fulvia Gloria-BottiniEgidio Bottini
Nov 4, 2008·The Medical Journal of Australia·Rachael-Anne Wills, Michael D Coory
Dec 25, 2008·Methods in Molecular Biology·Jeffrey S Chang
Jan 17, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ali DelpishehBernard J Brabin

❮ Previous
Next ❯

Citations

Mar 5, 2014·American Journal of Reproductive Immunology : AJRI·Ramkumar MenonIstvan Boldogh
Jul 23, 2015·BioMed Research International·Mariana G Braz, Bensu Karahalil
Sep 29, 2021·Basic & Clinical Pharmacology & Toxicology·Bensu KarahalilSevgi Akaydin Yardim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.