Associations Between Gut Microbiota and Alzheimer's Disease: Current Evidences and Future Therapeutic and Diagnostic Perspectives

Journal of Alzheimer's Disease : JAD
Liang Shen, Hong-Fang Ji

Abstract

Developing novel agents for unexplored targets to combat Alzheimer's disease (AD) represents an urgent task due to its increasing prevalence worldwide. The present paper summarizes the latest studies emerged in the past few years investigating the associations between the "forgotten organ" gut microbiota and AD from the following two aspects: 1) the associations between gut microbiota and AD development by animal models and human studies; and 2) the effects of gut microbiota modulation-based intervention for AD. Then, we propose future perspectives in two promising research areas: 1) developing gut microbiota modulation-based intervention; and 2) developing gut microbiota-associated diagnostic biomarkers for AD. Knowledge gaps and potential barriers to overcome towards these two goals are also discussed.

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Citations

Feb 1, 2020·Digestive Diseases and Sciences·Jessica Galloway-Peña, Blake Hanson
Feb 26, 2020·Applied Microbiology and Biotechnology·Zhen-Zhen SunHong-Fang Ji
Sep 29, 2020·Frontiers in Neurology·Hae Won KimJae Cheon Jeon
Jul 3, 2020·Journal of Clinical Medicine·Yixi HeShengdi Chen
Dec 8, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cristofer Ruiz-GonzalezDiana Cardona
Oct 2, 2021·Applied Microbiology and Biotechnology·Hong-Fang Ji, Liang Shen

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Methods Mentioned

BETA
transgenic
PCR

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