Associations between HDL oxidation and paraoxonase-1 and paraoxonase-1 gene polymorphisms in families affected by familial combined hyperlipidemia

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
M L LiuM R Taskinen

Abstract

It has been shown in vitro that the HDL-bound enzyme paraoxonase-1 (PON1) protects LDL against oxidation, and PON1 and PON1 gene polymorphisms may affect the oxidation of HDL particles. The aim of this study was to investigate the associations between in vitro HDL oxidation parameters, endogenous PON1 and PON1 genotypes in families affected by asymptomatic FCHL. Serum arylesterase (ARE) and PON1 activities, PON1 mass, PON1 genotypes and the kinetics of CuSO4-induced HDL oxidation in vitro were measured in 150 members of FCHL families free of clinical CAD. At univariate analysis, log PON1/apoA-I and the PON1 mass/apoA-I ratio significantly correlated with lag time, maximum diene formation and the propagation rate. The oxidation parameters also correlated with PON1 genotypes. Multivariate analysis showed that the associations between PON1 mass/unit apoA-I and the oxidation parameters were independent of the other variables. The lag time of HDL oxidation was also associated with the PON1 genotype 192QR. Endogenous PON1 may have protective effects on the different stages of HDL oxidation in the members of families affected by FCHL. This protective effect is independent of other biochemical factors, but may be influenced by the PON1...Continue Reading

References

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Citations

Jul 2, 2005·Current Opinion in Lipidology·Michael Aviram, Mira Rosenblat
Sep 25, 2010·Lipids in Health and Disease·Nakanishi ShuheiMarja-Riitta Taskinen
Jul 11, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Giuseppe Danilo NorataAlberico Luigi Catapano
Feb 15, 2012·Nature Reviews. Endocrinology·Martijn C G J BrouwersAnton F H Stalenhoef
Dec 28, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·You LiZhiyong Zhang

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