Associations Between Histogram Analysis DCE MRI Parameters and Complex 18 F-FDG-PET Values in Head and Neck Squamous Cell Carcinoma

Anticancer Research
Alexey SurovSandra Purz

Abstract

To analyze associations between parameters of positron-emission tomography (PET) and histogram analysis values of dynamic contrast-enhanced (DCE) imaging in patients with head and neck squamous cell carcinoma (HNSCC). Overall, 28 patients with primary HNSCC of different localizations were involved. 18F-FDG-PET/CT and DCE MR imaging were performed for all patients. Histogram analysis parameters of DCE MRI were calculated. Spearman's correlation coefficient was used to analyze the associations between investigated parameters. In the overall cohort, SUVmax correlated with Kep P10 (ρ=0.43, p=0.027), Kep P25 (0.40, p=0.035), and had a tendency to correlate with median Kep (ρ=0.33, p=0.098). TLG tended to correlate with Kep P25 (0.33, p=0.09) and P10 Ktrans (ρ=0.35, p=0.07). In G1/2 tumors, SUVmax correlated with Kep P10 (ρ=0.645, p=0.032), and tended to correlate with Ktrans mean (ρ=0.54, p=0.089), Ktrans min (ρ=0.58, p=0.06), Ktrans P10 (ρ=0.56, p=0.07), Ktrans P25 (ρ=0.59, p=0.056), and Ktrans median (ρ=0.054, p=0.089), as well with Kep min (ρ=0.56, p=0.07). SUVmean tended to correlate with Kep kurtosis (ρ=0.56, p=0.07). In G3 tumors, no tendencies or statistically significant correlations between the PET and DCE MRI parameters we...Continue Reading

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