Associations between hypothalamic-pituitary-adrenal axis function and peak bone mass at 20years of age in a birth cohort

Bone
Kun ZhuJohn P Walsh

Abstract

In older adults, high-normal circulating cortisol levels are associated with lower bone mass, but relationships between hypothalamic-pituitary-adrenal axis function and peak bone mass in young adults have not been examined. We studied 411 male and 390 female participants in the Western Australia Pregnancy Cohort (Raine) Study. At 18years of age, participants underwent a Trier Social Stress Test (TSST) with measurement of plasma and salivary cortisol at baseline and at multiple time points after stress. Cortisol responses were classified as anticipatory responder (significant fall in cortisol during the test), reactive responder (significant increase) or non-responder. At 20years, total body bone mineral content (BMC) and density (BMD) were measured by DXA. In males, after adjustment for weight, height (for BMC and bone area only), alcohol and smoking, there was a significant inverse relationship between both plasma and salivary cortisol measured at baseline in the TSST and each of BMC and BMD, such that each additional 10% of salivary cortisol was associated with reductions of 6.9g (95% CI -11.7, -2.2) in BMC, and 1.8mg/cm(2) (95% CI -3.3, -0.4) in BMD. Males classified as anticipatory responders in the TSST had 3.2% lower BMC ...Continue Reading

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Citations

Jul 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Jose A Rosa-ParraMartha M Téllez-Rojo
Oct 6, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kristina AnevskaTania Romano
Nov 12, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·James K Gibb, Eric C Shattuck

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