PMID: 9166114May 1, 1997Paper

Associations between insulin-like growth factor-I (IGF-I), IGF-binding protein-1, insulin and other metabolic measures after controlling for genetic influences: results from middle-aged and elderly monozygotic twins

The Journal of Endocrinology
Y HongU de Faire

Abstract

It has previously been shown that the serum levels of insulin-like growth factor-I (IGF-I), IGF-binding protein-1 (IGFBP-1), and insulin are influenced by genetic effects to various degrees. From a clinical and preventive point of view, however, it is important to identify potentially modifiable non-genetic factors influencing the levels of these measures. Because monozygotic twin pairs share the same genetic background, differences in phenotypic levels within monozygotic twin paris are believed to be due to non-genetic influences. Accordingly, the associations between intrapair differences in one phenotype and intrapair differences in another phenotype are also due to non-genetic influences. The present sample of 97 pairs of monozygotic twins from the population-based Swedish Adoption/Twin Study of Aging (SATSA) provided the opportunity to assess non-genetic influences on the levels of IGF-I, IGFBP-1, and insulin. Several metabolic measures were found to account for the variation of IGF-I, IGFBP-1, and insulin after controlling for the genetic influences. IGFBP-1 and glucose were significant predictors for the levels of IGF-I. IGFBP-1 and glucose together explained about one quarter of the non-genetic variation of IGF-I. Howev...Continue Reading

Citations

Dec 6, 2008·The British Journal of Nutrition·Alison K GosbyIan D Caterson
Aug 25, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D RosskopfH Wallaschofski
Dec 13, 2005·Nature Reviews. Cancer·D J HunterUNKNOWN National Cancer Institute Breast and Prostate Cancer Cohort Consortium
Dec 4, 2002·Clinical Endocrinology·Anna-Lena UndenKerstin Brismar
Sep 25, 2002·Journal of Internal Medicine·P LichtensteinN L Pedersen
Jun 26, 2004·Breast Cancer Research : BCR·Chi-Chen HongNorman F Boyd
Jun 22, 2016·Journal of Cardiac Failure·Ulrika Ljung FaxénLars H Lund
Dec 7, 2017·European Journal of Endocrinology·Rikke Beck JensenThomas Scheike
Jan 25, 2020·Experimental Physiology·Shuen Yee LeeChin Leong Lim

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