Associations between leptin and self-rated health in men and women

Gender Medicine
Anna Nixon AndréassonMats Lekander

Abstract

As an important mediator by which the brain receives information about the body's energy state, leptin may be associated with subjectively perceived health. The main aim of the present study was to investigate concurrent and prospective associations between leptin and self-rated health (SRH), a strong predictor of morbidity and mortality, in a random population sample. An additional aim was to examine whether sick leave was associated with leptin and poor SRH. In a prospective, population-based cohort study in Sweden, men and women underwent a medical examination in 1998, at which time blood was drawn and participants were asked to respond to a questionnaire concerning demographics, health behavior, and psychosocial factors. In 2000, the participants responded to a second questionnaire sent by postal mail. Spearman rank correlations were used to investigate the relationships between leptin, SRH, sick leave, and background variables. Partial Spearman coefficients were then calculated to investigate the patterns of association between leptin, SRH, and sick leave independent of age, body mass index (BMI), presence of diagnosis, and testosterone or estradiol. A total of 98 men and 104 women, aged 23 to 76 years, and 91 men and 96 w...Continue Reading

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