Associations between lipid/lipoprotein levels and perfluoroalkyl substances among US children aged 6-11 years

Environmental Pollution
Ram B Jain, Alan Ducatman

Abstract

Observed levels of lipid/lipoproteins are known to be associated with exposure to perfluoroalkyl substances (PFAS). In order to evaluate and update these associations among US children aged 6-11 years, data (N = 458) from National Health and Nutrition Examination Survey for 2013-2014 were used. The associations between the observed levels of total cholesterol, high density lipoprotein (HDL) cholesterol, and non-HDL cholesterol and selected PFAS were studied. PFAS data were available for perfluorononanoic acid (PFNA), perfluorohexane sulfonate (PFHxS), linear isomer of perfluorooctanoic acid (PFOA), linear isomer of perfluorooctane sulfonate (PFOS), monomethyl branch isomer of PFOS, and sum of PFAS. Regression models were fitted to evaluate these associations. A statistically significant (p = 0.03) positive association between the levels of linear isomer of PFOS and total cholesterol was observed. A 10% increase in the levels of linear isomer of PFOS measured in ng/L was found to be accompanied by a 0.03-0.42% increase in the levels of total cholesterol measured in mg/dL. For PFNA, girls in the first quartile of PFNA were found to have lower adjusted levels for total cholesterol than the girls in the fourth quartile of PFNA (152...Continue Reading

Citations

Jan 19, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marianne G PouwerHans M G Princen
Sep 20, 2019·The Journal of Clinical Endocrinology and Metabolism·Miranda J SpratlenLeonardo Trasande

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