Associations between lipodystrophy or antiretroviral medications and cirrhosis in patients with HIV infection or HIV/HCV coinfection

European Journal of Gastroenterology & Hepatology
George N IoannouEdward J Boyko

Abstract

Many HIV antiretroviral medications have been associated with chronic liver injury. HIV-infected patients frequently develop HIV and highly active antiretroviral treatment-associated lipodystrophy syndrome (HALS), characterized by accumulation of intra-abdominal fat, insulin resistance, and hepatic steatosis. We sought to determine whether long-term exposure to specific antiretroviral medications or the presence of HALS predispose HIV-infected patients to the development of cirrhosis. HIV-infected patients with cirrhosis who received care in the Veterans Affairs Healthcare System nationally in 2009 were matched by hepatitis C virus (HCV) coinfection status and year of first visit for HIV to the Veterans Affairs Healthcare System with HIV-infected patients without cirrhosis in a 1 : 3 ratio. Among HIV/HCV coinfected patients (593 with cirrhosis and 1591 matched controls), HALS was associated with a significantly increased risk for cirrhosis (adjusted odds ratio 1.6, 95% confidence interval 1.1-2.3), especially among Black patients (adjusted odds ratio 2.9, 95% confidence interval 1.6-5.2). In addition, among HIV/HCV coinfected patients, longer cumulative exposures to all antiretroviral medications, all nucleoside reverse transcr...Continue Reading

References

Jan 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kenneth A LichtensteinUNKNOWN HIV Outpatient Study Investigators
Jan 28, 2003·Progress in Lipid Research·David Y Hui
Jan 19, 2005·The American Journal of Gastroenterology·Jennifer R KramerHashem B El-Serag
Nov 13, 2007·Alimentary Pharmacology & Therapeutics·J R KramerH B El-Serag
Dec 7, 2007·The New England Journal of Medicine·Julian FalutzSteven Grinspoon
Mar 8, 2008·Gastroenterology·Wenyu LinRaymond T Chung
Apr 24, 2008·American Journal of Physiology. Endocrinology and Metabolism·Ksenia SevastianovaHannele Yki-Järvinen
Dec 17, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick IngilizYves Benhamou
Dec 16, 2010·Current Opinion in Infectious Diseases·Eugenia VispoVincent Soriano
Jun 23, 2011·Journal of Viral Hepatitis·M A LokoUNKNOWN ANRS CO 13 HEPAVIH Study Group
Apr 26, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George N IoannouEdward J Boyko
Sep 25, 2012·HIV Medicine·R WeberUNKNOWN Swiss HIV Cohort Study (SHCS)

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.