Associations between loneliness and personality are mostly driven by a genetic association with Neuroticism

Journal of Personality
Abdel AbdellaouiJohn T Cacioppo

Abstract

Loneliness is an aversive response to a discrepancy between desired and actual social relationships and correlates with personality. We investigate the relationship of loneliness and personality in twin family and molecular genetic data. Phenotypic correlations between loneliness and the Big Five personality traits were estimated in 29,625 adults, and in a group with genome-wide genotype data (N = 4,222), genetic correlations were obtained. We explored whether genetic correlations may reflect causal relationships by investigating within monozygotic twin pair differences (Npairs  = 2,662), by longitudinal within-subject changes in personality and loneliness (N = 4,260-9,238 longitudinal comparisons), and by longitudinal cross-lagged panel analyses (N = 15,628). Finally, we tested whether genetic correlations were due to cross-trait assortative mating (Nspouse pairs  = 4,436). The strongest correlations with loneliness were observed for Neuroticism (r = .55) and Extraversion (r = -.33). Only Neuroticism showed a high correlation with loneliness independent of other personality traits (r = .50), so follow-up analyses focused on Neuroticism. The genetic correlation between loneliness and Neuroticism from genotyped variants was .71;...Continue Reading

References

Jun 1, 1992·Journal of Personality·R R McCrae, O P John
Jul 1, 1991·Journal of Personality and Social Psychology·R J Larsen, T Ketelaar
May 1, 1988·Behavior Genetics·K PhillipsC T Nagoshi
Jan 1, 1986·Journal of Chronic Diseases·D R JacobsR W Carlaw
Sep 1, 1980·Journal of Personality and Social Psychology·D RussellC E Cutrona
Dec 17, 1998·Psychological Medicine·H H MaesL J Eaves
Jul 2, 2002·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Alan J ChristensenWilliam J Lawton
Dec 18, 2002·Journal of Neurobiology·Thomas J Bouchard, Matt McGue
Jul 23, 2003·Journal of Personality and Social Psychology·Louise C HawkleyJohn T Cacioppo
Aug 16, 2006·Journal of Health Psychology·Renee D Goodwin, Howard S Friedman
Sep 6, 2006·Clinical Psychology Review·Liesl M Heinrich, Eleonora Gullone
Dec 6, 2006·Journal of Personality and Social Psychology·Colin G DeYoung
Mar 16, 2007·Journal of Personality·Mathias AllemandChristopher Hertzog
May 28, 2008·Research on Aging·Mary Elizabeth HughesJohn T Cacioppo
Aug 6, 2008·Archives of General Psychiatry·Marleen H M De MoorEco J C de Geus
Nov 11, 2008·Annals of the New York Academy of Sciences·Elin Lehrmann, William J Freed
Dec 6, 2008·Nature Medicine·Catherine J Pallen
Sep 4, 2009·Trends in Cognitive Sciences·John T Cacioppo, Louise C Hawkley
Feb 11, 2010·Behavior Genetics·Marijn A DistelDorret I Boomsma
Apr 19, 1947·Lancet·H J EYSENCK
May 19, 2010·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Gonneke WillemsenDorret I Boomsma
Jun 22, 2010·Nature Genetics·Jian YangPeter M Visscher
Jul 24, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Louise C Hawkley, John T Cacioppo
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Nov 16, 2011·Psychological Assessment·Chakadee WaiyavuttiIan J Deary
Jan 10, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Gonneke WillemsenDorret I Boomsma
Mar 28, 2013·European Journal of Human Genetics : EJHG·Abdel AbdellaouiDorret I Boomsma
Aug 28, 2013·Behavior Genetics·Abdel AbdellaouiDorret I Boomsma
Sep 27, 2013·Cognition & Emotion·John T CacioppoDorret I Boomsma
May 20, 2014·Social and Personality Psychology Compass·John T Cacioppo, Stephanie Cacioppo
Jun 12, 2014·European Journal of Human Genetics : EJHG·Camelia C MinicăJacqueline M Vink
Aug 26, 2014·Annual Review of Psychology·John T CacioppoSteven W Cole
Sep 16, 2014·Psychological Bulletin·Stephanie CacioppoJohn T Cacioppo
Mar 31, 2015·Psychological Methods·Ellen L HamakerRaoul P P P Grasman
Apr 25, 2015·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Luc GoossensDorret I Boomsma
Apr 25, 2015·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Julianne Holt-LunstadDavid Stephenson
May 20, 2015·Nature Genetics·Tinca J C PoldermanDanielle Posthuma
May 21, 2015·JAMA Psychiatry·UNKNOWN Genetics of Personality ConsortiumDorret I Boomsma

❮ Previous
Next ❯

Citations

Mar 16, 2019·Social Cognitive and Affective Neuroscience·Chunliang FengPengfei Xu
Oct 15, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Julie M KittelsrudGareth E Davies
Sep 14, 2019·Human Molecular Genetics·Abdel AbdellaouiDorret I Boomsma
Mar 25, 2018·Genes, Brain, and Behavior·A AbdellaouiJ T Cacioppo
Jun 11, 2019·Personality and Social Psychology Review : an Official Journal of the Society for Personality and Social Psychology, Inc·Marcus MundFranz J Neyer
Jul 19, 2020·Neuroscience and Biobehavioral Reviews·Christian MontagSebastian Markett
Mar 9, 2021·Frontiers in Psychology·Xin ChenLiang Zhai
Oct 5, 2021·Frontiers in Genetics·Alice J KimChristopher R Beam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved