PMID: 20632462Jul 16, 2010Paper

Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women.

Menopause : the Journal of the North American Menopause Society
Roksana KarimWendy J Mack

Abstract

Hormone therapy has been shown to reduce markers of vascular inflammation in . C-reactive protein (CRP), a marker of generalized inflammation, is raised by oral estradiol therapy (ET). It is not known how sex hormone concentrations relate to the markers of inflammation in postmenopausal women taking or not taking hormone therapy. This observational study includes postmenopausal women participating in the Estrogen in the Prevention of Atherosclerosis Trial. Multiple measures of serum sex hormone and sex hormone-binding globulin(SHBG) levels from 107 postmenopausal women taking oral ET and 109 taking placebo for 2 years were correlated with markers of inflammation over the same time period using generalized estimating equations. Levels of soluble intercellular adhesion molecule-1 were significantly inversely associated with estrone(P = 0.05), total and free estradiol (P = 0.008 and 0.02, respectively), and SHBG (P = 0.03) only among oral ET users. Serum homocysteine levels were also inversely associated with estrone (P = 0.001) and total and free estradiol (P = 0.0006 and 0.0009, respectively) in ET-treated women only. No such associations were observed among women taking placebo. CRP was positively associated with estrogens and ...Continue Reading

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Citations

Dec 24, 2010·Current Opinion in Nephrology and Hypertension·Xiao-Ping Yang, Jane F Reckelhoff
Feb 2, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chun-Hou LiaoWen-Ya Ma
Dec 17, 2011·The American Journal of the Medical Sciences·Olivia R HenryLynne Jones
Jan 29, 2013·Joint, Bone, Spine : Revue Du Rhumatisme·Marta Martín-Millán, Santos Castañeda
Mar 6, 2012·Clinical Cardiology·Martha GulatiC Noel Bairey Merz
Oct 23, 2016·International Journal of Cancer. Journal International Du Cancer·Britton TrabertNicolas Wentzensen
Jan 30, 2018·The Journal of Nutrition·Martha TamezMartin Lajous

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