Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth

Clinical Epigenetics
Polina GirchenkoKatri Räikkönen

Abstract

A recent study has shown that it is possible to accurately estimate gestational age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn blood spots. This DNAm GA predictor may provide additional information relevant to developmental stage. In 814 mother-neonate pairs, we evaluated the associations between DNAm GA and a number of maternal and offspring characteristics. These characteristics reflect prenatal environmental adversity and are expected to influence newborn developmental stage. DNAm GA acceleration (GAA; i.e., older DNAm GA than chronological GA) of the offspring at birth was associated with maternal age of over 40 years at delivery, pre-eclampsia and fetal demise in a previous pregnancy, maternal pre-eclampsia and treatment with antenatal betamethasone in the index pregnancy, lower neonatal birth size, lower 1-min Apgar score, and female sex. DNAm GA deceleration (GAD; i.e., younger DNAm GA than chronological GA) of the offspring at birth was associated with insulin-treated gestational diabetes mellitus (GDM) in a previous pregnancy and Sjögren's syndrome. These findings were more accentuated when the DNAm GA calculation was based on the raw difference between DNAm GA and GA than on th...Continue Reading

References

Nov 17, 1990·BMJ : British Medical Journal·D J Barker
Aug 16, 1997·BMJ : British Medical Journal·J W Rich-EdwardsC H Hennekens
Mar 26, 2003·American Journal of Physical Anthropology·Noël Cameron, Ellen W Demerath
Oct 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Avan Aihie SayerCyrus Cooper
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Mar 12, 2010·Genome Research·Andrew E TeschendorffMartin Widschwendter
Mar 12, 2010·Genome Research·Vardhman K RakyanTimothy D Spector
Jan 11, 2011·Human Molecular Genetics·Dena G HernandezAndrew B Singleton
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·S A S LangieJ C Mathers
Oct 5, 2012·Genome Biology·Steve HorvathRoel A Ophoff
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lucia L LamMichael S Kobor
Oct 16, 2012·Aging Cell·Paolo GaragnaniClaudio Franceschi
Oct 27, 2012·Rejuvenation Research·Adiv A JohnsonJoão Pedro de Magalhães
Nov 7, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·P M VillaUNKNOWN PREDO Study group
Nov 28, 2012·Molecular Cell·Gregory HannumKang Zhang
Sep 27, 2013·JAMA Psychiatry·Brian M D'OnofrioPaul Lichtenstein
Oct 22, 2013·Genome Biology·Steve Horvath
Jan 31, 2014·Genetic Epidemiology·Richard T BarfieldKaren N Conneely
Oct 15, 2014·Proceedings of the National Academy of Sciences of the United States of America·Steve HorvathJochen Hampe
Dec 3, 2014·Atherosclerosis·Silvia VisentinErich Cosmi
Jan 27, 2015·International Journal of Epidemiology·Riccardo E MarioniIan J Deary
Mar 29, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Kelly M BakulskiM Daniele Fallin
Apr 15, 2016·International Journal of Epidemiology·Riccardo E MarioniIan J Deary
Aug 12, 2016·Genome Biology·Steve HorvathThemistocles L Assimes
Sep 18, 2016·International Journal of Epidemiology·Polina GirchenkoKatri Räikkönen
Oct 26, 2016·Development and Psychopathology·Renaud MassartMoshe Szyf
Oct 9, 2016·Genome Biology·Anna K KnightAlicia K Smith

❮ Previous
Next ❯

Citations

Nov 23, 2017·Development and Psychopathology·Sarah R MooreMichael S Kobor
Jan 18, 2020·Journal of Developmental Origins of Health and Disease·Tsegaselassie WorkalemahuFasil Tekola-Ayele
Jun 13, 2019·Nature Communications·Darina CzamaraElisabeth B Binder
Aug 10, 2019·Aging·Fasil Tekola-AyeleGermaine M Buck Louis
Jun 15, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Christy-Lynn M Cooke, Sandra T Davidge
May 27, 2020·Journal of Developmental Origins of Health and Disease·Maja PopovicLorenzo Richiardi
Sep 22, 2017·Clinical Epigenetics·Andrew J SimpkinLaura D Howe
Mar 9, 2021·Ageing Research Reviews·Rezvan NorooziEwelina Pośpiech
May 1, 2021·Clinical Epigenetics·Linda DieckmannDarina Czamara
Jun 3, 2021·International Journal of Environmental Research and Public Health·Andrea MaugeriAntonella Agodi
Sep 15, 2021·Chinese Medical Journal·Jing Wang, Wen-Hao Zhou

❮ Previous
Next ❯

Methods Mentioned

BETA
cesarean section
genotyping

Software Mentioned

DNAm
R
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Obstetricia Et Gynecologica Scandinavica
Sven SchneiderHolger Maul
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
X XiongN N Demianczuk
© 2022 Meta ULC. All rights reserved