Associations between metabolic acidosis at birth and reduced Apgar scores within the normal range (7-10): A Swedish cohort study of term non-malformed infants.

Paediatric and Perinatal Epidemiology
Sven CnattingiusNeda Razaz

Abstract

Risks of neonatal and long-term neurological outcomes are influenced by metabolic acidosis at birth and by reduced Apgar scores, even within the normal range (7-10). To analyse associations between metabolic acidosis at birth and risks of reduced Apgar scores within the normal range. In a Swedish cohort of term non-malformed infants born between 2008 and 2013, we included 81 861 infants with information from cord blood gas analyses and Apgar score values of 7-10 at 1, 5, and 10 minutes. Poisson log-linear regression analyses were used to examine associations between metabolic acidosis at birth (defined as pH <7.05 or <7.10 and base deficit ≥12) and Apgar scores of 7, 8, and 9. Adjusted risk ratio (RR) and 95% confidence intervals (C). were calculated. Compared with infants without metabolic acidosis, the adjusted RR of an Apgar score of 9 at 5 minutes was 3.14 (95% CI 2.57, 3.84) in infants with metabolic acidosis (pH <7.05 as cut-off), and 10.13 (95% CI 7.63, 13.45) and 7.60 (95% CI 3.54, 16.33) for Apgar scores of 8 and 7, respectively. Corresponding RRs of Apgar scores at 10 minutes were also substantially increased. The magnitude of RDs varied, but was consistently increased. Both reduced Apgar scores and metabolic acidosis...Continue Reading

References

Apr 1, 1988·The Journal of Pediatrics·E Blair, F J Stanley
Feb 15, 2001·The New England Journal of Medicine·B M CaseyK J Leveno
Mar 1, 1960·Acta Paediatrica. Supplement·L S JAMES
Mar 30, 2006·Epidemiology·Yuelian SunJørn Olsen
May 25, 2006·Clinical Obstetrics and Gynecology·Eugenia K Pallotto, Howard W Kilbride
Oct 3, 2006·The Journal of Pediatrics·Colm P F O'DonnellColin J Morley
Oct 24, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·L Armstrong, B J Stenson
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Jul 8, 2011·Obstetrics and Gynecology·Andrea StuartKarin Källen
Oct 24, 2012·Revista da Associação Médica Brasileira·Eugenia Maria Assunção SalustianoMarcelo Zugaib
Aug 26, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Tomas Prior, Sailesh Kumar
Jan 21, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·O StephanssonS Cnattingius
Jul 19, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Neda RazazK S Joseph
Sep 30, 2015·Pediatrics·UNKNOWN AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON FETUS AND NEWBORN, UNKNOWN AMERICAN COLLEGE OF OBSTETRICIANS AND GYNECOLOGISTS COMMITTEE ON OBSTETRIC PRACTICE
Jan 16, 2016·European Journal of Epidemiology·Jonas F LudvigssonWeimin Ye
Jun 4, 2016·American Journal of Obstetrics and Gynecology·Bethany A Sabol, Aaron B Caughey
Dec 3, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·B SkiöldS Johansson
Mar 8, 2017·JAMA : the Journal of the American Medical Association·Eduardo VillamorSven Cnattingius
Apr 7, 2017·JAMA Neurology·Neda RazazSven Cnattingius
Jun 18, 2017·Paediatric and Perinatal Epidemiology·Ayesha SiddiquiUNKNOWN Euro-Peristat Scientific Committee
Feb 14, 2018·BMJ : British Medical Journal·Martina PerssonSven Cnattingius
Oct 7, 2018·European Journal of Epidemiology·Amirhossein ModabberniaAbraham Reichenberg

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Citations

Apr 28, 2020·Paediatric and Perinatal Epidemiology·Heather A Frey
Jun 26, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Han-Yang Chen, Suneet P Chauhan

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