Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study.

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Terril L VerplaetseSherry A McKee

Abstract

Nicotine metabolite ratio (NMR), the ratio of trans 3'-hydroxycotinine to cotinine, is a biomarker of nicotine metabolism. Discrepant findings among clinical trials and population-based studies warrant replication on whether higher NMR, or faster nicotine metabolism, is associated with quitting cigarette smoking. Associations of NMR and e-cigarette use are largely unknown, as well as the relationship between NMR and gender on quitting cigarette smoking or e-cigarette use. The Population Assessment of Tobacco and Health (PATH) Study is a nationally representative, longitudinal cohort study assessing tobacco use in the US population. In the current study, the PATH (waves 1 and 2; adult interviews) was used to evaluate longitudinal predictions in relationships among NMR and gender and their association with transitions (quit vs. current stable) in cigarette smoking status and e-cigarette use status across waves 1 and 2 of the PATH study. NMR and gender were not significantly associated with quit behavior for combustible cigarettes. Regarding e-cigarettes, a significant two-way interaction demonstrated that women with higher NMR were less likely to quit e-cigarette use compared to women with lower NMR (odds ratio [OR] = 0.10, 95% c...Continue Reading

References

Aug 31, 2002·Psychopharmacology·Kenneth A PerkinsAnthony R Caggiula
Jul 2, 2004·Clinical Pharmacology and Therapeutics·Delia DempseyNeal L Benowitz
May 9, 2006·Clinical Pharmacology and Therapeutics·Neal L BenowitzPeyton Jacob
Jun 13, 2006·Clinical Pharmacology and Therapeutics·Caryn LermanNeal Benowitz
Jan 9, 2007·Journal of Pharmacokinetics and Pharmacodynamics·Micha LeviLewis B Sheiner
Feb 27, 2007·American Journal of Epidemiology·Denise B KandelNeal L Benowitz
Jul 17, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kenneth A Perkins, John Scott
Nov 13, 2008·Pharmacology, Biochemistry, and Behavior·Robert A SchnollCaryn Lerman
Jan 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrew A StrasserCaryn E Lerman
Mar 2, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Brian A KingShanta R Dube
Apr 15, 2014·Tobacco Control·Philip H SmithSherry A McKee
Nov 9, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Robert C McMillenJonathan D Klein
Mar 4, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Diana A HamiltonLarry W Hawk
May 28, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julie-Anne TannerRachel F Tyndale
Jun 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Meghan J ChenowethRachel F Tyndale
Aug 11, 2016·Tobacco Control·Andrew HylandWilson M Compton
Aug 26, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Esther PapaseitSimona Pichini
Apr 8, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Brian V FixJames F Thrasher
May 20, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Suzaynn F SchickAruni Bhatnagar
Jan 19, 2018·MMWR. Morbidity and Mortality Weekly Report·Ahmed JamalLinda J Neff
Jun 7, 2018·Addictive Behaviors·Kenneth A PerkinsJoshua L Karelitz

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Citations

Sep 1, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Thomas F NorthrupGeorg E Matt
Dec 17, 2020·Expert Opinion on Drug Metabolism & Toxicology·Yadira X Perez-Paramo, Philip Lazarus

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