Associations between occupational exposure to benzene, toluene and xylene and risk of lung cancer in Montréal

Occupational and Environmental Medicine
Hunter WardenVikki Ho

Abstract

Benzene, toluene and xylene (BTX) are aromatic hydrocarbons with inconclusive evidence of lung carcinogenicity. The aim of this research was to assess the associations between occupational exposures to BTX agents and lung cancer. In a population-based case-control study of lung cancer, occupational histories were obtained and exposures were assessed by experts. Unconditional multivariate logistic regression was used to estimate ORs and 95% CIs, among men, between various metrics of occupational exposure to BTX and lung cancer, while adjusting for established and possible risk factors. Considerable overlap was found between occupational exposure to BTX, where the majority of exposed participants were exposed to all three chemicals. Lung cancer was associated with exposure to benzene (OR=1.35; 95% CI 0.99 to 1.84), toluene (OR=1.31; 95% CI 0.99 to 1.74) and xylene (OR=1.44; 95% CI 1.03 to 2.01). While these results were adjusted for smoking and other recognised and possible lung cancer risk factors, they were not mutually adjusted among the three BTX agents. Our study provides suggestive evidence that occupational exposure to one or more of the BTX agents may be associated with lung cancer.

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Citations

Dec 20, 2019·BMC Pharmacology & Toxicology·Angela Maria MoroSolange Cristina Garcia
Aug 28, 2020·Occupational and Environmental Medicine·Mengting XuJack Siemiatycki
Nov 17, 2020·Frontiers in Genetics·Temitope H AdebamboAdebayo A Otitoloju
Jan 12, 2021·Zeitschrift für Gesundheitswissenschaften = Journal of public health·Micah O OmareFredrick O Kengara
Jul 3, 2021·International Journal of Environmental Research and Public Health·Steffen MuellerShujun Liu
Oct 21, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Banrida WahlangMathew C Cave

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