Associations between pediatric choledochal cysts, biliary atresia, and congenital cardiac anomalies.

The Journal of Surgical Research
Andrew J MurphyHarold N Lovvorn

Abstract

In our institutional experience treating pediatric choledochal cysts over the past 12 y, we noted that seven of 32 patients (21.9%) had comorbid congenital cardiac anomalies. This association has not been previously described other than in isolated case reports. We aimed to quantify this association on a national level. We queried the 2009 Healthcare Cost and Utilization Project Kids' Inpatient Database. We identified patients with a diagnosis of choledochal cyst (ICD-9-CM 75169, 75162, and 75160) or biliary atresia (75161). We defined cardiac anomalies using the Clinical Classification Software code (CCS 213). Comorbid choledochal cysts or biliary atresia and congenital cardiac anomalies were quantified in both infant (<12 mo) and child (1-18 y) subpopulations. Of 1646 estimated discharges for patients with choledochal cysts, 506 (30.7%) were for patients who also had congenital cardiac anomalies, compared with 2.6% in the general hospitalized population (χ(2); P < 0.001). The frequency of congenital cardiac anomalies was lower in 1973 hospitalizations for biliary atresia (13.8%) than in those for patients with choledochal cysts (χ(2); P < 0.001). We detected cardiac anomalies in 44.9% of choledochal cyst hospitalizations for ...Continue Reading

References

Sep 1, 1973·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·D P BabbittA R Clemett
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Nov 24, 1999·American Journal of Medical Genetics·S KimE Chen
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Nov 11, 2008·Pediatric Transplantation·Niramol TantemsapyaRiccardo Superina
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Aug 9, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Orlee R GuttmanUNKNOWN Canadian Pediatric Hepatology Research Group

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Citations

Dec 3, 2014·Journal of the American College of Surgeons·Kevin C SoaresTimothy M Pawlik
Apr 17, 2016·Archives of Disease in Childhood·Aya M FattouhHanaa El-Karaksy
Apr 2, 2017·Pediatric Surgery International·Kevin C SoaresTimothy M Pawlik
Jul 22, 2020·Archives of Disease in Childhood·Bashar AldeiriMark Davenport

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