Associations between perfluorinated chemicals and serum biochemical markers and performance status in uremic patients under hemodialysis

PloS One
Wen-Sheng LiuTsung-Yun Liu

Abstract

Perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) are commonly used perfluorinated chemicals (PFCs). PFCs are mainly excreted by urine. Uremic patients tend to accumulate toxins in their body and have poor functional status. We investigated the associations between PFCs and the clinical profile of uremic patients under hemodialysis (HD). Liquid chromatography tandem mass spectrometry coupled with isotope dilution was used to quantify PFOA and PFOS. We enrolled 126 patients under regular HD. Compared with previous research, the concentration of PFOA was lower, but that of PFOS was higher in uremic patients than in the general population. The levels of PFOA and PFOS in uremic patients before dialysis were 0.52 (ng/ml) and 21.84 (ng/ml) respectively. The PFOA level remained unchanged but that of PFOS decreased to1.85 ng/mL after dialysis. PFOS can be removed by HD. Patients using hypertensive medication had a lower PFOS then those who did not. The PFOS level was negatively correlated with the duration of the HD session and patient performance status, but positively correlated with levels of cholesterol, chloride (an indicator of acidemia), ferritin, and total protein. (p<0.05). The association with serum protein ma...Continue Reading

References

Jan 1, 1988·Biomaterials, Artificial Cells, and Artificial Organs·E E Schneeberger
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Oct 8, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·J L ButenhoffP J Thomford
Feb 28, 2006·Journal of the Air & Waste Management Association·Catherine A BartonMary Kaiser
Mar 5, 2008·International Journal of Andrology·Allan Astrup Jensen, Henrik Leffers
May 16, 2009·BMC Structural Biology·Ling-Ling WuLing Chen
Jul 11, 2009·Environmental Health Perspectives·Ulla Nordström JoensenNiels Jørgensen
Sep 15, 2009·Environmental Health Perspectives·Renée DallairePierre Ayotte
Dec 17, 2009·The American Journal of Gastroenterology·Chien-Yu LinPau-Chung Chen
Aug 30, 2011·American Journal of Epidemiology·Anoop ShankarAlan Ducatman
Oct 18, 2011·Clinical Epidemiology·Anoop ShankarAlan Ducatman
Aug 11, 2012·PloS One·Mei-Huei ChenWu-Shiun Hsieh
Nov 23, 2013·Environment International·Deborah J WatkinsKarl T Kelsey
Mar 14, 2014·Environmental Science and Pollution Research International·Jia BaoGuang-Hui Dong
Jan 7, 2017·SICOT-J·Saroj RaiHong Wang
Jul 6, 2017·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Di MengGang Han
Jul 10, 2017·International Journal of Hygiene and Environmental Health·Jin Heon LeeSuk-Nam Choi

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Citations

Sep 17, 2019·Current Opinion in Critical Care·Fiorenza FerrariClaudio Ronco
Nov 21, 2018·International Journal of Environmental Research and Public Health·Wen-Sheng LiuTsung-Yun Liu

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