Abstract
Testosterone has in recent years been proven essential for normal growth and maturation of small growing follicles. Concomitantly, low functional ovarian reserve (LFOR), characterized by a small growing follicle pool, has been associated with low testosterone levels, which can be of ovarian and/or adrenal origin. In this study we, therefore, investigated whether peripheral sex steroid precursors and testosterone levels potentially reflect on adrenal function. In a retrospective cohort study of 355 consecutive infertile women, who presented to an academically affiliated fertility center in New York City, we investigated in a series of statistical models whether low peripheral sex steroid precursors and testosterone are associated with peripheral cortisol (C) levels, reflecting adrenal function. To determine potential correlations, we investigated the dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione (AD), total testosterone (TT), free testosterone (FT); sex hormone binding globulin (SHBG), anti-Müllerian hormone (AMH), thyroid stimulating hormone (TSH) and C in a series of multivariate and logistic regression analyses, utilizing C either as a continuous variable or with cut off <5.0μg/dL, and TT only as a cont...Continue Reading
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Citations
Apr 27, 2016·Reproductive Biology and Endocrinology : RB&E·Norbert GleicherDavid H Barad
Dec 21, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Norbert GleicherDavid H Barad
Sep 16, 2017·The Journal of Clinical Endocrinology and Metabolism·Norbert GleicherDavid H Barad
Aug 20, 2016·American Journal of Reproductive Immunology : AJRI·Mario VegaNorbert Gleicher
Jan 7, 2018·Endocrine·Norbert GleicherDavid H Barad
Jun 21, 2017·Stress : the International Journal on the Biology of Stress·Marcus K TaylorPaul Sargent
Oct 13, 2018·Endocrine·Vitaly A KushnirNorbert Gleicher