Associations between persistent organic pollutants and risk of breast cancer metastasis

Environment International
Meriem KoualXavier Coumoul

Abstract

Breast cancer (BC) is a major public health concern with over 2 million new cases diagnosed and over 600,000 deaths in 2018 in women worldwide. When distant metastases are present at diagnosis, the 5-year survival rate is only 26%. Recent studies have suggested that persistent organic pollutants (POPs) that accumulate in adipose tissue (AT) can influence tumor phenotype and stimulate cellular processes important for metastasis such as invasion. We, therefore, tested the hypothesis that POP exposure is associated with BC metastasis. We conducted an exploratory case-control study in which the concentrations of 49 POPs were measured in both AT and serum samples from BC patients, with or without lymph node metastasis, who underwent partial or total mastectomies, lymph node biopsies and sampling of the adipocytic tumor microenvironment. Adjusted, unconditional logistic models were used to study the associations between the POP concentrations and the risk of metastasis and other hallmarks of cancer aggressiveness. 2.3.7.8-TCDD concentrations in AT are positively associated with the risk of metastasis in 43 patients who have BMIs equal or higher than 25 kg/m2 (odds ratio: 4.48 (1.32-20.71)). Furthermore, the concentrations of 2.3.7.8-...Continue Reading

Citations

Aug 26, 2020·Environmental Technology·Dajun RenXiangyi Gong
Dec 10, 2020·Gut Microbes·Yuan TianAndrew D Patterson
Apr 11, 2020·International Journal of Hygiene and Environmental Health·Humberto ParadaMelissa A Troester
Nov 19, 2020·Environmental Health : a Global Access Science Source·Meriem KoualXavier Coumoul
Feb 23, 2021·European Journal of Clinical Investigation·Lingchen WangMinzhang Cheng
Mar 19, 2021·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx
Apr 17, 2021·Critical Reviews in Oncology/hematology·Priscilla Roberta Silva RochaAngélica Amorim Amato
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Stephan MarquardtStella Logotheti
Aug 7, 2021·Frontiers in Endocrinology·Emma BokobzaNicolas Chevalier
Oct 17, 2021·The Science of the Total Environment·Sara SousaValentina F Domingues

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