PMID: 20134100Feb 6, 2010Paper

Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis

Journal of Atherosclerosis and Thrombosis
Yukihiko MomiyamaFumitaka Ohsuzu

Abstract

Limited correlations between C-reactive protein (CRP) and coronary artery disease (CAD) have been reported. Recently, MRI became a useful tool for non-invasively evaluating atherosclerotic plaques in thoracic and abdominal aortas. To elucidate the associations between plasma CRP levels and the severities of coronary and aortic atherosclerosis, we performed aortic black-blood MRI in 136 patients undergoing coronary angiography. For each patient, 9 slices of thoracic aorta and 9 slices of abdominal aorta were obtained at 12-mm intervals, and the plaque extent in each slice was scored. The degree of aortic atherosclerosis is represented as the sum of scores. The degree of coronary atherosclerosis is represented as the number of >50% stenotic vessels and >25% stenotic segments. CAD (>50% stenosis) was present in 96 patients. Patients with CAD had higher CRP levels than those without CAD (median 0.78 vs. 0.48 mg/L, p<0.02). CRP levels tended to increase depending on the number of stenotic vessels: 0.48, 0.70, 0.74, and 0.88 mg/L (p=NS). CRP correlated weakly with the number of stenotic segments (r=0.21). Regarding aortic atherosclerosis, 136 patients were divided into quartiles by plaque score. CRP levels increased stepwise in quart...Continue Reading

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Citations

Jul 24, 2012·Endocrine·Sazan RasulAlexandra Kautzky-Willer
Feb 18, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Dilshad Ahmed KhanFarooq Ahmed Khan
Sep 18, 2010·Mediators of Inflammation·Zhaoxia Wang, Tomohiro Nakayama
Nov 3, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Qi Kong, Xin Ma
Jan 13, 2015·Clinical Medicine Insights. Cardiology·Reiko OhmoriYukihiko Momiyama
Jan 13, 2011·European Journal of Clinical Nutrition·C Stryjecki, D M Mutch
Aug 28, 2020·Journal of Atherosclerosis and Thrombosis·Yoshiharu NishimuraMitsugi Nagashima
Jun 25, 2021·Stroke; a Journal of Cerebral Circulation·Peter J KellyGeorgios Tsivgoulis

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