Associations between prenatal mercury exposure and early child development in the ALSPAC study.

Neurotoxicology
Jean GoldingCaroline M Taylor

Abstract

There is evidence that high levels of mercury exposure to the pregnant woman can result in damage to the brain of the developing fetus. However there is uncertainty as to whether lower levels of the metal have adverse effects on the development of the infant and whether components of fish consumption and/or the selenium status of the woman is protective. In this study we analysed data from the Avon Longitudinal Study of Parents and Children (ALSPAC) (n=2875-3264) to determine whether levels of total blood mercury of pregnant women collected in the first half of pregnancy are associated with the development of the offspring at ages 6, 18, 30 and 42 months. The developmental measures used maternal self-reported scales for individual types of development (fine and gross motor, social and communication skills) and total scores. Multiple and logistic regression analyses treated the outcomes both as continuous and as suboptimal (the lowest 15th centile). The statistical analyses first examined the association of prenatal mercury exposure with these developmental endpoints and then adjusted each for a number of social and maternal lifestyle factors; finally this model was adjusted for the blood selenium level. Total maternal prenatal ...Continue Reading

References

Aug 1, 1967·The Journal of Pediatrics·W K Frankenburg, J B Dodds
Jul 1, 1998·Environmental Health Perspectives·G J Myers, P W Davidson
Mar 10, 2001·Paediatric and Perinatal Epidemiology·J GoldingUNKNOWN ALSPAC Study Team
Jul 3, 2004·Epidemiology·Julie L DanielsUNKNOWN ALSPAC Study Team. University of Bristol Institute of Child Health
Sep 6, 2005·Developmental Medicine and Child Neurology·Alan EmondUNKNOWN ALSPAC Study Team
Oct 6, 2005·Environmental Health Perspectives·Emily OkenMatthew W Gillman
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Jul 3, 2013·Environmental Health Perspectives·Jean GoldingRobert Jones
May 23, 2014·Journal of Developmental Origins of Health and Disease·C M TaylorA M Emond
Dec 22, 2015·Community Dentistry and Oral Epidemiology·Jean GoldingCaroline M Taylor

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Citations

Jun 3, 2016·International Journal of Hygiene and Environmental Health·Caroline M TaylorAlan M Emond
Oct 31, 2016·International Journal of Hygiene and Environmental Health·Iman Al-SalehMichael Nester
Mar 27, 2018·Public Health Nutrition·Caroline M TaylorJean Golding
May 5, 2018·Paediatric and Perinatal Epidemiology·Gloria Isabel Niño CruzIná S Santos
Dec 1, 2018·Biological Trace Element Research·Monika UrsinyovaMartin Gajdos
Jun 6, 2017·Journal of Korean Medical Science·Kyoung Sook JeongYangho Kim
May 2, 2018·Molecular Autism·Jean GoldingCaroline Taylor

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