Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-ethnic Study of Atherosclerosis (MESA).

Environmental Health Perspectives
Amy H AuchinclossMarie S O'Neill

Abstract

Blood pressure (BP) may be implicated in associations observed between ambient particulate matter and cardiovascular morbidity and mortality. This study examined cross-sectional associations between short-term ambient fine particles (particulate matter <or= 2.5 microm in aerodynamic diameter; PM(2.5)) and BP: systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse pressure (PP). The study sample included 5,112 persons 45-84 years of age, free of cardiovascular disease at the Multi-Ethnic Study of Atherosclerosis baseline examination (2000-2002). Data from U.S. Environmental Protection Agency monitors were used to estimate ambient PM(2.5) exposures for the preceding 1, 2, 7, 30, and 60 days. Roadway data were used to estimate local exposures to traffic-related particles. Results from linear regression found PP and SBP positively associated with PM(2.5). For example, a 10-microg/m(3) increase in PM(2.5) 30-day mean was associated with 1.12 mmHg higher pulse pressure [95% confidence interval (CI), 0.28-1.97] and 0.99 mmHg higher systolic BP (95% CI, -0.15 to 2.13), adjusted for age, sex, race/ethnicity, income, education, body mass index, diabetes, cigarette smoking and environmental tobacco smoke, alcohol use, physical ac...Continue Reading

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