Associations between resting-state functional connectivity and treatment response in a randomized clinical trial for posttraumatic stress disorder.

Depression and Anxiety
Jony SheyninIsrael Liberzon

Abstract

Alterations in resting-state functional connectivity (rsFC) have been reported in posttraumatic stress disorder (PTSD). Here, we examined pre- and post-treatment rsFC during a randomized clinical trial to characterize alterations and examine predictors of treatment response. Sixty-four combat veterans with PTSD were randomly assigned to prolonged exposure (PE) plus placebo, sertraline plus enhanced medication management, or PE plus sertraline. Symptom assessment and resting-state functional magnetic resonance imaging (fMRI) scans occurred before and after treatment. Twenty-nine trauma-exposed combat veterans without PTSD served as a control group at intake. Seed-based and region of interest (ROI)-to-ROI connectivities, as well as an exploratory connectome-based approach were used to analyze rsFC patterns. Based on previously reported findings, analyses focused on Salience Network (SN) and Default-Mode Network (DMN). At intake, patients with PTSD showed greater DMN-dorsal attention network (DAN) connectivity (between ventromedial prefrontal cortex and superior parietal lobule; family-wise error corrected p = .011), greater SN-DAN connectivity (between insula and middle frontal gyrus; corrected p = .003), and a negative correlati...Continue Reading

Associated Clinical Trials

Feb 1, 2012·Sheila Rauch

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Citations

Feb 11, 2021·Journal of Neurophysiology·Joseph W Tu
Apr 21, 2021·Depression and Anxiety·S J H van RooijPaul E Holtzheimer
Jun 17, 2021·NeuroImage. Clinical·T A A BroedersC H Vinkers
Oct 7, 2021·Translational Psychiatry·Alyssa R RoecknerJennifer S Stevens

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