Associations between Retinal Markers of Microvascular Disease and Cognitive Impairment in Newly Diagnosed Type 2 Diabetes Mellitus: A Case Control Study

PloS One
Vasanth Venkat NaiduRobert Stewart

Abstract

To investigate associations between retinal microvascular changes and cognitive impairment in newly diagnosed type 2 diabetes mellitus. Case control study. A primary care cohort with newly diagnosed type 2 diabetes mellitus. For this analysis, we compared 69 cases with lowest decile scores (for the cohort) on the Modified Telephone Interview for Cognitive Status and 68 controls randomly selected from the remainder of the cohort. Retinal images were rated and the following measures compared between cases and controls: retinal vessel calibre, arterio-venous ratio, retinal fractal dimension, and simple and curvature retinal vessel tortuosity. Total and venular (but not arteriolar) simple retinal vessel tortuosity levels were significantly higher in cases than controls (t = 2.45, p = 0.015; t = 2.53, p = 0.013 respectively). The associations persisted after adjustment for demographic factors, retinopathy, neuropathy, obesity and blood pressure. There were no other significant differences between cases and controls in retinal measures. A novel association was found between higher venular tortuosity and cognitive impairment in newly diagnosed type 2 diabetes mellitus. This might be accounted for by factors such as hypoxia, thrombus f...Continue Reading

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Citations

Feb 2, 2018·PloS One·Evelyn Li Min TaiIsmail Shatriah
Feb 8, 2019·Current Medicinal Chemistry·Jiyin ZhouGuisheng Qian
May 14, 2020·Neural Plasticity·Xin HuangYin Shen

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Methods Mentioned

BETA
coronary artery bypass
amputation

Software Mentioned

SIVA
Statistical Package of the Social Sciences ( SPSS )

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