Associations Between Serum 25-Hydroxyvitamin D, Insulin Sensitivity, Insulin Secretion, and β-Cell Function According to Glucose Tolerance Status

Metabolic Syndrome and Related Disorders
Anne-Sophie MorissetClaudia Gagnon

Abstract

The objective of this study was to determine whether glucose tolerance status influences the associations between serum 25-hydroxyvitamin D [25(OH)D], insulin sensitivity, insulin secretion, and β-cell function. This cross-sectional study included 112 French Canadian postmenopausal women with normal glucose tolerance (NGT; n = 65) or abnormal glucose tolerance (AGT; n = 47). Estimates of insulin sensitivity [homeostasis model assessment of insulin sensitivity (HOMA %S) and glucose disposal rate (GDR)], insulin secretion [area under the curve of C-peptide (AUC C-peptide)], and β-cell function (GDR × AUC C-peptide) were derived from a 2-hr euglycemic-hyperinsulinemic clamp and a 75-gram 3-hr oral glucose tolerance test (OGTT). Measures of adiposity were taken (waist circumference, body mass index, fat mass by the hydrostatic weighting technique, and computed tomography (CT)-derived total and visceral adiposity), questionnaires on physical activity, dietary calcium, and vitamin D intake were administered, and blood was sampled for measurement of parathyroid hormone, interleukin-6, and adiponectin. AGT status was significantly associated with lower insulin sensitivity and β-cell function (P ≤ 0.01 for all) but not with insulin secr...Continue Reading

References

Nov 1, 1971·The Journal of Clinical Endocrinology and Metabolism·B Desbuquois, G D Aurbach
Mar 1, 1983·The American Journal of Clinical Nutrition·C BouchardG Thériault
Jan 1, 1956·Advances in Biological and Medical Physics·W E SIRI
Apr 29, 2004·The American Journal of Clinical Nutrition·Ken C ChiuMohammed F Saad
Jun 27, 2009·Nutrition Research Reviews·Dorothy Teegarden, Shawn S Donkin
Jan 13, 2010·Postgraduate Medical Journal·Zehra Ozfirat, Tahseen A Chowdhury
Mar 23, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Anastassios G Pittas, Bess Dawson-Hughes
Mar 24, 2012·The American Journal of Clinical Nutrition·Cynthia A LamendolaGerald M Reaven
Oct 4, 2012·Diabetes Care·Mayer B DavidsonTheodore C Friedman

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy
enzyme-linked immunosorbent assays

Software Mentioned

Food Processor Nutrition Analysis
JMP

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.