Associations between serum C-reactive protein and serum zinc, ferritin, and copper in Guatemalan school children.

Biological Trace Element Research
Vinh Q BuiReynaldo Martorell

Abstract

Inflammation affects trace nutrient concentrations, but research on copper and particularly in children is limited. We assessed associations between serum C-reactive protein (CRP) and zinc, iron, copper, and other biomarkers (alkaline phosphatase, hemoglobin, and albumin), in 634 healthy 6- to 11-year-old Guatemalan schoolchildren. CRP was measured by a standardized, high-sensitive method. For significant associations with CRP, we stratified nutrient concentrations across categories of CRP and compared concentrations above and below several CRP cutoff points (0.5, 1, 3, 5, and 10 mg/L), and then adjusted values using correction factors (ratios of geometric means of the nutrients in the low and high groups). Prevalence of serum zinc (<65 μg/dL0, ferritin (<15 μg/L), and copper (<90 μg/dL) deficiency were 21%, 2.1%, and 23.8%, respectively. Median (25th and 75th percentiles) CRP was 0.56 (0.26 and 1.54) mg/L. CRP concentration was positively associated with ferritin and copper concentrations (r = 0.23 and 0.29, respectively; P < 0.0001) but not with zinc and other biomarkers (P > 0.05). Regardless of CRP cutoffs, high (> cutoff) vs. low (≤ cutoff) CRP levels had higher ferritin and copper concentrations and lower prevalence of co...Continue Reading

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Citations

Feb 9, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Leslie M Klevay
Sep 12, 2015·Journal of Nutrition and Metabolism·Imane El MenchawyHassan Aguenaou
Dec 2, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jiexiu ZhaoYufeng Luo
Feb 28, 2016·Biological Trace Element Research·Xiaobing LiuXiaoguang Yang
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Mar 11, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·You-Fan PengGuo-Gang Pan
Jun 19, 2013·Food and Nutrition Bulletin·Alex BritoManuel Olivares
Jan 3, 2019·Biological Trace Element Research·Eliel Marcio PedroMaria Josefa Santos

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