Jan 1, 2014

Associations between serum cholesterol levels and cerebral amyloidosis

JAMA Neurology
Bruce R ReedWilliam Jagust

Abstract

Because deposition of cerebral β-amyloid (Aβ) seems to be a key initiating event in Alzheimer disease (AD), factors associated with increased deposition are of great interest. Whether elevated serum cholesterol levels act as such a factor is unknown. To investigate the association between serum cholesterol levels and cerebral Aβ during life early in the AD process. A multisite, university medical center-based, cross-sectional analysis of potential associations between contemporaneously assayed total serum cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and cerebral Aβ, measured with carbon C11-labeled Pittsburgh Compound B (PIB) positron emission tomography. Seventy-four persons (mean age, 78 years) were recruited via direct outreach in stroke clinics and community senior facilities following a protocol designed to obtain a cohort enriched for cerebrovascular disease and elevated vascular risk. Three patients had mild dementia. All others were clinically normal (n = 33) or had mild cognitive impairment (n = 38). Cerebral Aβ was quantified using a Global PIB Index, which averages PIB retention in cortical areas prone to amyloidosis. Statistical models that controlled for ag...Continue Reading

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Mentioned in this Paper

Prevalence Studies
N-methyl-(11C)2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Familial Alzheimer Disease (FAD)
Epicholesterol
APP protein, human
Positron-Emission Tomography
Coronary Artery Disease
Amyloidosis
Autopsy
Blood Vessel

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