Associations between serum concentration of flavonoids and breast cancer risk among Chinese women.

European Journal of Nutrition
Xiao-Li FengCai-Xia Zhang

Abstract

In vitro and in vivo studies suggested that flavonols, flavones, flavanones and flavan-3-ols have preventive effects on breast carcinogenesis. Epidemiological evidence about the associations between these flavonoid biomarkers and breast cancer risk is limited. This study aimed to investigate the association between serum concentration of these flavonoids and breast cancer risk among Chinese women. This hospital-based case-control study recruited 792 breast cancer cases and 813 age frequency-matched (5-year interval) controls who provided eligible blood samples in Guangdong Province, China. Ultra-high-performance liquid chromatography-tandem mass spectrometry was used to measure flavonoids. Unconditional logistic regression was used to estimate the odds ratio (OR) and 95% confidence internal (CI). Higher concentrations of serum flavonols, isorhamnetin, kaempferol, flavanones and naringenin were significantly associated with lower breast cancer risk, with adjusted ORs (95% CIs) for the highest versus the lowest group of 0.66 (0.49-0.89) for flavonols, 0.52 (0.38-0.70) for isorhamnetin, 0.60 (0.45-0.80) for kaempferol, 0.65 (0.49-0.87) for flavanones and 0.45 (0.34-0.60) for naringenin, respectively. Significant positive associati...Continue Reading

References

Sep 19, 2000·Medicine and Science in Sports and Exercise·B E AinsworthA S Leon
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Anna H WuMalcolm C Pike
Oct 2, 2003·The Journal of Nutrition·Gary R Beecher
Oct 2, 2003·British Journal of Cancer·J PetersonD Trichopoulos
Oct 21, 2004·Free Radical Research·Claudine Manach, Jennifer L Donovan
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Clement A AdebamowoMichelle D Holmes
Mar 4, 2005·Biological & Pharmaceutical Bulletin·Syu-Ichi KannoMasaaki Ishikawa
Apr 13, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cristina BosettiCarlo La Vecchia
Dec 13, 2006·American Journal of Epidemiology·Brian N FinkMarilie D Gammon
Aug 2, 2007·The British Journal of Nutrition·Jeremy P E SpencerJohn C Mathers
May 21, 2008·International Journal of Cancer. Journal International Du Cancer·Gretchen J CutlerKim Robien
Dec 17, 2008·The Journal of Nutrition·Martha J ShrubsoleWei Zheng
Aug 5, 2009·Breast Cancer Research and Treatment·Jianfeng LuoQi Dai
May 5, 2010·Breast Cancer Research and Treatment·Motoki IwasakiShoichiro Tsugane
Jun 19, 2010·Archives of Biochemistry and Biophysics·Joshua D Lambert, Ryan J Elias
Mar 15, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chung S YangHuanyu Jin
Jun 18, 2011·Medicine and Science in Sports and Exercise·Barbara E AinsworthArthur S Leon
Oct 9, 2012·Cell Biochemistry and Function·Yong YangMauro Ferrari
Aug 31, 2013·Nutrients·Surangi H Thilakarathna, H P Vasantha Rupasinghe
Aug 16, 2014·Pharmacognosy Reviews·Katrin Sak
Apr 18, 2015·International Journal of Cancer. Journal International Du Cancer·Jin-Kyoung OhElisabete Weiderpass
Apr 24, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Jinhai ZhuTingjing Yao
Jan 23, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xie-An YuYan-Xu Chang
Aug 11, 2017·European Journal of Medicinal Chemistry·Demetrio RaffaGiuseppe Daidone
Sep 28, 2017·Asian Pacific Journal of Cancer Prevention : APJCP·Katrin Sak
Jun 8, 2018·Phytotherapy Research : PTR·Mona Najaf NajafiMajid Khadem-Rezaiyan
Nov 19, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Xiao-Li FengCai-Xia Zhang
Mar 19, 2020·Nutrients·Priyanga SelvakumarAshakumary Lakshmikuttyamma

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Citations

Mar 13, 2021·The American Journal of Clinical Nutrition·Luo-Shi-Yuan ZuoYu-Ming Chen
Jan 6, 2021·Menopause : the Journal of the North American Menopause Society·Xiao-Li FengCai-Xia Zhang

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