Associations between serum IL-8 and knee symptoms, joint structures, and cartilage or bone biomarkers in patients with knee osteoarthritis

Clinical Rheumatology
Guangfeng RuanC Ding

Abstract

The aim of this study was to investigate cross-sectional associations between serum levels of IL-8 and the above outcomes in patients with knee osteoarthritis (OA). A total of 160 subjects with clinical knee OA were included. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and Lequesne index were used to assess the joint symptom. Magnetic resonance imaging was used to measure knee structural abnormalities including infrapatellar fat pad (IPFP) signal intensity alternation. Knee radiographic OA was assessed by radiography using the Kellgren-Lawrence (K-L) grading system. Enzyme-linked immunosorbent assay was used to measure the serum levels of IL-8 and cartilage or bone biomarkers. In multivariable analyses, serum IL-8 was positively associated with WOMAC weight-bearing pain (β 2.85, P = 0.028), WOMAC physical dysfunction (β 12.71, P = 0.048), and Lequesne index (β 1.65, P = 0.015), and had positive associations with IPFP signal intensity alteration (OR 3.18, P = 0.011) and serum levels of N-telopeptide of type I collagen (NTXI), N-terminal procollagen III propeptide (PIIINP), matrix metalloproteinase (MMP)3, and MMP13 (β 0.24-1.44, all P < 0.05) in patients with clinical knee OA. Furthermore, there ...Continue Reading

References

Dec 7, 2000·Cytokines, Cellular & Molecular Therapy·S KanekoJ Kagawa
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Feb 20, 2004·Osteoarthritis and Cartilage·C G PeterfyH K Genant
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Aug 20, 2016·Nature Reviews. Rheumatology·William H RobinsonJeremy Sokolove
Apr 24, 2017·Osteoarthritis and Cartilage·Y Y LeungV B Kraus

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Citations

Oct 31, 2020·Pain Management·Marina Fayet, Martina Hagen

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