Associations between serum leptin levels, hyperlipidemia, and cholelithiasis in dogs

PloS One
Sungin LeeW H Kim

Abstract

Leptin and its receptor play several physiological roles in the canine gallbladder, and the dysregulation of leptin might play a role in the pathogenesis of gallbladder diseases such as gallbladder mucocele. Previous studies revealed a positive association between hyperlipidemia and gallstones in humans. However, the latter is still unclear in dogs with cholelithiasis. In this study, we examined the differences in leptin, leptin receptor, total cholesterol, and triglyceride levels between healthy dogs and dogs with cholelithiasis, and evaluated the correlation between leptin and hyperlipidemia. Twenty-eight healthy dogs and 34 client-owned dogs with cholelithiasis were enrolled in the study. Leptin concentrations and lipid profiles were determined from sera, and leptin and leptin receptor expression levels were quantified in gallbladder tissue. In dogs with cholelithiasis, serum concentrations of leptin (p < 0.001), total cholesterol (p < 0.001), and triglycerides (p < 0.001) were significantly higher compared with those in healthy dogs. Positive correlations were observed between serum leptin and total cholesterol (95% confidence interval (CI) = 0.61-0.89, r = 0.725, p < 0.001), and between leptin and triglycerides (95% CI = 0...Continue Reading

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Citations

Oct 4, 2019·Journal of Veterinary Internal Medicine·Rosario LucenaPedro José Ginel
May 17, 2019·International Journal of Molecular Sciences·Laura CorteseAlessandra Pelagalli
Nov 11, 2020·International Journal of Molecular Sciences·Ming-Ling ChangSien-Sing Yang
Jun 17, 2021·Experimental and Therapeutic Medicine·Lei HuangXinmin Si
Oct 30, 2021·Journal of Veterinary Internal Medicine·Frederik AllanKatie E McCallum
Dec 23, 2021·The Journal of Small Animal Practice·J A Jaffey

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
X-ray
ELISA
PCR

Software Mentioned

SPSS

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