Associations between severe co-morbidity and muscle measures in advanced non-small cell lung cancer patients

Journal of Cachexia, Sarcopenia and Muscle
Bjørn H GrønbergMarit Jordhøy

Abstract

Studies show that low skeletal muscle index (SMI) and low skeletal muscle density (SMD) are negative prognostic factors and associated with more toxicity from systemic therapy in cancer patients. However, muscle depletion can be caused by a range of diseases, and many cancer patients have significant co-morbidity. The aim of this study was to investigate whether there were associations between co-morbidity and muscle measures in patients with advanced non-small cell lung cancer. Patients in a Phase III trial comparing two chemotherapy regimens in advanced non-small cell lung cancer were analysed (n = 436). Co-morbidity was assessed using the Cumulative Illness Rating Scale for Geriatrics (CIRS-G), which rates co-morbidity from 0 to 4 on 14 different organ scales. Severe co-morbidity was defined as having any grades 3 and 4 CIRS-G score. Muscle measures were assessed from baseline computed tomography slides at the L3 level using the SliceOMatic software. Complete data were available for 263 patients (60%). Median age was 66, 57.0% were men, 78.7% had performance status 0-1, 25.9% Stage IIIB, 11.4% appetite loss, 92.4% were current/former smokers, 22.8% were underweight, 43.7% had normal weight, 26.6% were overweight, and 6.8% ob...Continue Reading

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Citations

Feb 12, 2020·Journal of Cachexia, Sarcopenia and Muscle·Chris BurtinDirk K M De Ruysscher
Oct 15, 2020·Der Internist·M S AnkerS von Haehling

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Software Mentioned

SPSS
SliceOMatic
CIRS

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