Associations between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review

Advances in Nutrition
Theresa DrabschChristina Holzapfel

Abstract

A better understanding of the genetic underpinning of total energy, carbohydrate, and fat intake is a prerequisite to develop personalized dietary recommendations. For this purpose, we systematically reviewed associations between single nucleotide polymorphisms (SNPs) and total energy, carbohydrate, and fat intakes. Four databases were searched for studies that assessed an association between SNPs and total energy, carbohydrate, and fat intakes. Screening of articles and data extraction was performed independently by 2 reviewers. Articles in English or German language, published between 1994 and September 2017, on human studies in adults and without specific populations were considered for the review. In total, 39 articles, including 86 independent loci, met the inclusion criteria. The fat mass and obesity-associated (FTO) gene as well as the melanocortin 4 receptor (MC4R) locus were most frequently studied. Limited significant evidence of an association between the FTO SNP rs9939609 and lower total energy intake and between the MC4R SNP rs17782313 and higher total energy intake was reported. Most of the other identified loci showed inconsistent results. In conclusion, there is no consistent evidence that the investigated SNPs ...Continue Reading

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Citations

Apr 2, 2020·Genes·Anna VesninaVictor Atuchin
Apr 3, 2020·Nature Reviews. Endocrinology·Rodrigo San-CristobalJosé Alfredo Martínez
Aug 28, 2020·Lipids in Health and Disease·Mahsa MehrdadMohammad Hassan Eftekhari
Oct 18, 2020·Nutrients·Leila KhorraminezhadIwona Rudkowska
Nov 14, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Birsen Yılmaz, Makbule Gezmen Karadağ
Jul 9, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yoriko HeianzaLu Qi

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