Associations between socioeconomic factors and proinflammatory cytokines in children, adolescents and young adults: a systematic review protocol

BMJ Open
Nick FredmanSharon L Brennan-Olsen

Abstract

There is now substantial evidence of a social gradient in bone health. Social stressors, related to socioeconomic status, are suggested to produce an inflammatory response marked by increased levels of proinflammatory cytokines. Here we focus on the particular role in the years before the achievement of peak bone mass, encompassing childhood, adolescence and young adulthood. An examination of such associations will help explain how social factors such as occupation, level of education and income may affect later-life bone disorders. This paper presents the protocol for a systematic review of existing literature regarding associations between socioeconomic factors and proinflammatory cytokines in those aged 6-30 years. We will conduct a systematic search of PubMed, OVID and CINAHL databases to identify articles that examine associations between socioeconomic factors and levels of proinflammatory cytokines, known to influence bone health, during childhood, adolescence or young adulthood. The findings of this review have implications for the equitable development of peak bone mass regardless of socioeconomic factors. Two independent reviewers will determine the eligibility of studies according to predetermined criteria, and studie...Continue Reading

References

Dec 25, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S L BrennanA E Wluka
Dec 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sharon L BrennanJulie A Pasco
Aug 21, 2009·Journal of Epidemiology and Community Health·Sharon L BrennanAnita E Wluka
Feb 11, 2012·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Sharon L BrennanJulie A Pasco
Feb 8, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C J CrandallA S Karlamangla
Jul 1, 2014·Psychosomatic Medicine·Hannah M C SchreierEdith Chen
Oct 26, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C M OliveiraM F Pina
Jan 13, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S L BrennanJ A Pasco
Jan 3, 2016·Bone·Sharon L Brennan-OlsenLana J Williams
Feb 10, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C M WeaverB S Zemel

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